Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children

被引：6

作者：

Fialho, Eder M. S. ^{[1
]}

Veras, Emanoel M. ^{[2
]}

de Jesus, Caroline M. ^{[3
]}

Gomes, Lillian N. ^{[4
]}

Khouri, Ricardo ^{[5
]}

Sousa, Patricia S. ^{[6
]}

Ribeiro, Marizelia R. C. ^{[7
]}

Batista, Rosangela F. L. ^{[8
]}

Costa, Luciana C. ^{[8
]}

Nascimento, Flavia R. F. ^{[1
,9
]}

Silva, Antonio A. M. ^{[8
]}

Soeiro-Pereira, Paulo V. ^{[1
,9
]}

机构：

[1] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Hlth Sci Grad Program, BR-65080805 Sao Luis, MA, Brazil

[2] Univ Fed Maranhao, Med Sch, BR-65080805 Sao Luis, MA, Brazil

[3] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Hlth & Technol Grad Program, BR-65080805 Sao Luis, MA, Brazil

[4] Univ Sao Paulo, Dept Immunol, BR-05508000 Sao Paulo, SP, Brazil

[5] FIOCRUZ Bahia, Goncalo Moniz Res Inst, BR-40296710 Salvador, BA, Brazil

[6] Reference Ctr Neurodev Assistance & Rehabil Childr, State Dept Hlth State Maranhao, BR-65077357 Sao Luis, MA, Brazil

[7] Univ Fed Maranhao, Dept Med 3, BR-65020240 Sao Luis, MA, Brazil

[8] Univ Fed Maranhao, Dept Publ Hlth, BR-65020060 Sao Luis, MA, Brazil

[9] Univ Fed Maranhao, Dept Pathol, BR-65065545 Sao Luis, MA, Brazil

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 06期

关键词：

vertical transmission; microcephaly; disease infection; interleukin-17; IMMUNE ACTIVATION; TRANSMISSION; EXPOSURE; DEFECTS; INFANTS; BRAZIL; BIRTH;

D O I：

10.3390/v15061320

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers' and children's immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers' immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.

引用

页数：16

共 50 条

[1] Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain [J].

Arrode-Bruses, Geraldine ;

Bruses, Juan L. .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[2] Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1 [J].

Azamor, Tamiris ;

Cunha, Daniela Prado ;

da Silva, Andrea Marques Vieira ;

Bezerra, Ohanna Cavalcanti de Lima ;

Ribeiro-Alves, Marcelo ;

Calvo, Thyago Leal ;

Kehdy, Fernanda de Souza Gomes ;

Manta, Fernanda Saloum de Neves ;

Pinto, Thiago Gomes de Toledo ;

Ferreira, Lais Pereira ;

Portari, Elyzabeth Avvad ;

Guida, Leticia da Cunha ;

Gomes, Leonardo ;

Moreira, Maria Elisabeth Lopes ;

de Carvalho, Elizeu Fagundes ;

Cardoso, Cynthia Chester ;

Muller, Marcelo ;

Ano Bom, Ana Paula Dinis ;

Neves, Patricia Cristina da Costa ;

Vasconcelos, Zilton ;

Moraes, Milton Ozorio .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[3] In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus [J].

Azevedo, Raimunda S. S. ;

de Sousa, Jorge R. ;

Araujo, Marialva T. F. ;

Martins Filho, Arnaldo J. ;

de Alcantara, Bianca N. ;

Araujo, Fernanda M. C. ;

Queiroz, Maria G. L. ;

Cruz, Ana C. R. ;

Baldez Vasconcelos, Beatriz H. ;

Chiang, Jannifer O. ;

Martins, Livia C. ;

Casseb, Livia M. N. ;

da Silva, Eliana V. ;

Carvalho, Valeria L. ;

Baldez Vasconcelos, Barbara C. ;

Rodrigues, Sueli G. ;

Oliveira, Consuelo S. ;

Quaresma, Juarez A. S. ;

Vasconcelos, Pedro F. C. .

SCIENTIFIC REPORTS, 2018, 8

[4] Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children [J].

Badolato-Correa, Jessica ;

Carvalho, Fabiana Rabe ;

Paiva, Iury Amancio ;

Familiar-Macedo, Debora ;

Dias, Helver Goncalves ;

Pauvolid-Correa, Alex ;

Fernandes-Santos, Caroline ;

Queiroz Lima, Monique da Rocha ;

Gandini, Mariana ;

Silva, Andrea Alice ;

Baeta Cavalcanti, Silvia Maria ;

de Oliveira, Solange Artimos ;

de Oliveira Vianna, Renata Artimos ;

de Azeredo, Elzinandes Leal ;

Cardoso, Claudete Aparecida Araujo ;

Grifoni, Alba ;

Sette, Alessandro ;

Weiskopf, Daniela ;

de-Oliveira-Pinto, Luzia Maria .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[5] Viral Concentration Determination Through Plaque Assays: Using Traditional and Novel Overlay Systems [J].

Baer, Alan ;

Kehn-Hall, Kylene .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2014, (93)

[6] Growth and Development of Children with Microcephaly Associated with Congenital Zika Virus Syndrome in Brazil [J].

Barbosa de Franca, Thais Lorena ;

Medeiros, Wilton Rodrigues ;

de Souza, Nilba Lima ;

Longo, Egmar ;

Pereira, Silvana Alves ;

de Oliveira Franca, Thamyris Barbosa ;

Sousa, Klayton Galante .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 15 (09)

[7]

Baud D, 2017, LANCET, V390, P2099, DOI [10.1016/S0140-6736(17)31450-2, 10.1016/s0140-6736(17)31450-2]

[8] Zika Virus Infection in Pregnant Women in Rio de Janeiro [J].

Brasil, P. ;

Pereira, J. P., Jr. ;

Moreira, M. E. ;

Ribeiro Nogueira, R. M. ;

Damasceno, L. ;

Wakimoto, M. ;

Rabello, R. S. ;

Valderramos, S. G. ;

Halai, U. -A. ;

Salles, T. S. ;

Zin, A. A. ;

Horovitz, D. ;

Daltro, P. ;

Boechat, M. ;

Gabaglia, C. Raja ;

Carvalho de Sequeira, P. ;

Pilotto, J. H. ;

Medialdea-Carrera, R. ;

Cotrim da Cunha, D. ;

Abreu de Carvalho, L. M. ;

Pone, M. ;

Machado Siqueira, A. ;

Calvet, G. A. ;

Rodrigues Baiao, A. E. ;

Neves, E. S. ;

Nassar de Carvalho, P. R. ;

Hasue, R. H. ;

Marschik, P. B. ;

Einspieler, C. ;

Janzen, C. ;

Cherry, J. D. ;

Bispo de Filippis, A. M. ;

Nielsen-Saines, K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (24) :2321-2334

[9] Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism [J].

Brown, Alan S. .

DEVELOPMENTAL NEUROBIOLOGY, 2012, 72 (10) :1272-1276

[10] Pregnant Women Infected with Zika Virus Show Higher Viral Load and Immunoregulatory Cytokines Profile with CXCL10 Increase [J].

Camacho-Zavala, Elizabeth ;

Santacruz-Tinoco, Clara ;

Munoz, Esteban ;

Chacon-Salinas, Rommel ;

Salazar-Sanchez, Ma Isabel ;

Grajales, Concepcion ;

Gonzalez-Ibarra, Joaquin ;

Borja-Aburto, Victor Hugo ;

Jaenisch, Thomas ;

Gonzalez-Bonilla, Cesar R. .

VIRUSES-BASEL, 2021, 13 (01)

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