The evolution of the COVID-19 pandemic in paediatric patients with sickle cell disease: From Alpha to Omicron

被引：0

作者：

Martin, Olufunke Y. ^{[1
,2
,4
]}

Margulies, Stefanie ^{[1
,2
]}

Speller-Brown, Barbara ^{[1
,2
,3
]}

Majumdar, Suvankar ^{[1
,2
,3
]}

Darbari, Deepika S. ^{[1
,2
,3
]}

Campbell, Andrew D. ^{[1
,2
,3
]}

机构：

[1] Childrens Natl Hosp, Washington, DC USA

[2] Ctr Canc & Blood Disorders, Div Hematol, Washington, DC USA

[3] George Washington Univ, Sch Med & Hlth Sci, Washington, DC USA

[4] Childrens Natl Hosp, 111 Michigan Ave NW, Washington, DC 20010 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年

关键词：

clinical research; COVID-19; pediatrics; sickle cell disease; UNITED-STATES; CORONAVIRUS DISEASE; TRANSMISSION;

D O I：

10.1111/bjh.18867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compare the impact of SARS-CoV-2 variants on healthcare utilization and clinical presentation in paediatric patients with sickle cell disease (SCD). One hundred and ninety-one unique patients with SCD and positive SARS-CoV-2 polymerase chain reactions were identified between March 2020 and January 2022. Hospitalizations, which accounted for 42% (N = 81) of cases, were highest during the Delta dominant era (48%) and lowest during Omicron (36%) (p = 0.285). The most common SCD-related complication was vaso-occlusive pain (37%, N = 71), which accounted for 51% of all hospital admissions (N = 41), and acute chest was highest in the Alpha variant era (N = 15). Overall, COVID-19 remained mild in clinical severity within most paediatric SCD patients.

引用

页码：479 / 484

页数：6

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