The evolution of the COVID-19 pandemic in paediatric patients with sickle cell disease: From Alpha to Omicron

被引：0
|
作者：
Martin, Olufunke Y. [1 ,2 ,4 ]
Margulies, Stefanie [1 ,2 ]
Speller-Brown, Barbara [1 ,2 ,3 ]
Majumdar, Suvankar [1 ,2 ,3 ]
Darbari, Deepika S. [1 ,2 ,3 ]
Campbell, Andrew D. [1 ,2 ,3 ]
机构：
[1] Childrens Natl Hosp, Washington, DC USA
[2] Ctr Canc & Blood Disorders, Div Hematol, Washington, DC USA
[3] George Washington Univ, Sch Med & Hlth Sci, Washington, DC USA
[4] Childrens Natl Hosp, 111 Michigan Ave NW, Washington, DC 20010 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2023年
关键词：
clinical research; COVID-19; pediatrics; sickle cell disease; UNITED-STATES; CORONAVIRUS DISEASE; TRANSMISSION;
D O I：
10.1111/bjh.18867
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We compare the impact of SARS-CoV-2 variants on healthcare utilization and clinical presentation in paediatric patients with sickle cell disease (SCD). One hundred and ninety-one unique patients with SCD and positive SARS-CoV-2 polymerase chain reactions were identified between March 2020 and January 2022. Hospitalizations, which accounted for 42% (N = 81) of cases, were highest during the Delta dominant era (48%) and lowest during Omicron (36%) (p = 0.285). The most common SCD-related complication was vaso-occlusive pain (37%, N = 71), which accounted for 51% of all hospital admissions (N = 41), and acute chest was highest in the Alpha variant era (N = 15). Overall, COVID-19 remained mild in clinical severity within most paediatric SCD patients.
引用
收藏
页码：479 / 484
页数：6
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