Ru(II)-Catalyzed One-Pot Synthesis of 1,2-Hydropyridines via a Three-Component Reaction

被引：1

作者：

Yang, Juntao ^{[1
]}

Liu, Bingxian ^{[1
]}

Chang, Junbiao ^{[1
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, NMPA Key Lab Res & Evaluat Innovat Drug, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 09期

基金：

中国博士后科学基金; 国家重点研发计划;

关键词：

H BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLES; ANNULATION; PYRIDINE; ALKYNES; UTILITY; IMINES;

D O I：

10.1021/acs.orglett.3c00216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium(II)-catalyzed one-pot synthesis of highly substituted 1,2-dihydropyridines (DHPs) via a three component reaction system has been realized. The reaction is conducted using a simple Ru(II) catalyst without the addition of specific ligands. The catalytic system exhibits good functionality tolerance with a wide range of starting materials. The DHPs obtained can be easily converted into tetrahydropyridines and azabicyclo[4.2.0]octa-4,7-dienes by subsequent reduction or [2 + 2] cycloaddition reaction.

引用

页码：1476 / 1480

页数：5

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