New advances in genomics and epigenetics in antiphospholipid syndrome

被引：5

作者：

Lopez-Pedrera, Chary ^{[1
,4
]}

Cerdo, Tomas ^{[1
,2
]}

Jury, Elizabeth C. ^{[2
]}

Munoz-Barrera, Laura ^{[1
]}

Escudero-Contreras, Alejandro ^{[1
]}

Aguirre, M. A. ^{[1
]}

Perez-Sanchez, Carlos ^{[1
,3
]}

机构：

[1] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba IMIBIC, Rheumatol Serv, Cordoba, Spain

[2] UCL, Ctr Rheumatol Res, Div Med, London, England

[3] Univ Cordoba, Dept Cell Biol Immunol & Physiol, Agrifood Campus Int Excellence, CeiA3, Cordoba, Spain

[4] Univ Cordoba, IMIBIC, Reina Sofia Univ Hosp, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain

来源：

RHEUMATOLOGY | 2024年 / 63卷 / SI期

关键词：

antiphospholipid syndrome; transcriptomics; microRNA; epigenetics; bioinformatics; SYSTEMIC-LUPUS-ERYTHEMATOSUS; EXPRESSION; THROMBOSIS; ACTIVATION; RECEPTORS; H3K9AC;

D O I：

10.1093/rheumatology/kead575

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

APS patients exhibit a wide clinical heterogeneity in terms of the disease's origin and progression. This diversity can be attributed to consistent aPL profiles and other genetic and acquired risk factors. Therefore, understanding the pathophysiology of APS requires the identification of specific molecular signatures that can explain the pro-atherosclerotic, pro-thrombotic and inflammatory states observed in this autoimmune disorder. In recent years, significant progress has been made in uncovering gene profiles and understanding the intricate epigenetic mechanisms and microRNA changes that regulate their expression. These advancements have highlighted the crucial role played by these regulators in influencing various clinical aspects of APS. This review delves into the recent advancements in genomic and epigenetic approaches used to uncover the mechanisms contributing to vascular and obstetric involvement in APS. Furthermore, we discuss the implementation of novel bioinformatics tools that facilitate the investigation of these mechanisms and pave the way for personalized medicine in APS.

引用

页码：SI14 / SI23

页数：10

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