SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection

被引：8

作者：

Baerends, Eva A. M. ^{[1
,2
]}

Hvidt, Astrid K. ^{[1
,2
]}

Reekie, Joanne ^{[3
]}

Sogaard, Ole S. ^{[1
,2
]}

Staerke, Nina B. ^{[1
,2
]}

Raben, Dorthe ^{[3
]}

Nielsen, Henrik ^{[4
,5
]}

Petersen, Kristine T. ^{[4
]}

Juhl, Maria R. ^{[4
]}

Johansen, Isik S. ^{[6
,7
]}

Lindvig, Susan O. ^{[6
,7
]}

Madsen, Lone W. ^{[6
,7
]}

Wiese, Lothar ^{[8
]}

Knudsen, Lene S. ^{[8
]}

Iversen, Mette B. ^{[8
]}

Benfield, Thomas ^{[9
,10
,11
]}

Iversen, Kasper K. ^{[9
,12
]}

Andersen, Sidsel D. ^{[1
,2
]}

Juhl, Anna K. ^{[1
,2
]}

Dietz, Lisa L. ^{[1
,2
]}

Andreasen, Signe R. ^{[1
,2
]}

Fischer, Thea K. ^{[10
,11
,13
]}

Erikstrup, Christian ^{[2
,14
]}

Valentiner-Branth, Palle ^{[15
]}

Lundgren, Jens ^{[3
,10
,11
,16
]}

Ostergaard, Lars ^{[1
,2
]}

Tolstrup, Martin ^{[1
,2
]}

机构：

[1] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark

[2] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[3] Univ Copenhagen, Ctr Excellence Hlth Immun & Infect, Rigshosp, Copenhagen, Denmark

[4] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark

[5] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[6] Odense Univ Hosp, Dept Infect Dis, Odense, Denmark

[7] Univ Southern Denmark, Dept Clin Res, Odense, Denmark

[8] Zealand Univ Hosp, Dept Med, Roskilde, Denmark

[9] Copenhagen Univ Hosp Amager & Hvidovre, Dept Infect Dis, Hvidovre, Denmark

[10] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[11] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[12] Herlev Hosp, Dept Cardiol & Emergency Med, Herlev, Denmark

[13] Nordsjaellands Hosp, Dept Clin Res, Hillerod, Denmark

[14] Aarhus Univ Hosp, Dept Clin Immunol, Aarhus, Denmark

[15] Statens Serum Inst, Dept Infect Dis Epidemiol & Prevent, Copenhagen, Denmark

[16] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Copenhagen, Denmark

来源：

ISCIENCE | 2023年 / 26卷 / 09期

关键词：

COVID-19;

D O I：

10.1016/j.isci.2023.107621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring the immunological requirements for protection against Omicron breakthrough infection. The test-negative matched case-control study (N = 964) characterized Omicron breakthrough infections in triple-vaccinated individuals from the ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower in cases compared to controls (GMR [95% CI] for BA.2: 0.83 [0.73-0.95], p = 0.006). Multivariable logistic regression showed significant associations between high antibody levels and lower odds of infection (aOR [95% CI] for BA.2 spike-specific IgG: 0.65 [0.48-0.88], p = 0.006 and BA.2 ACE2-blocking antibodies: 0.46 [0.30-0.69], p = 0.0002). A sex-stratified analysis showed more pronounced associations for females than males. High levels of vaccine-induced antibodies provide partial protection against Omicron breakthrough infections. This is important knowledge to further characterize a threshold for protection against new variants and to estimate the necessity and timing of booster vaccination.

引用

页数：14

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