Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review

被引：10

作者：

Tamborlane, William ^{[1
]}

Shehadeh, Naim ^{[2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Pediat, New Haven, CT USA

[2] Inst Diabet Endocrinol & Metab, Rambam Hlth Care Campus, POB 9602, IL-3109601 Haifa, Israel

[3] Bar Ilan Univ, Azrieli Fac Med, Safed, Israel

来源：

ADVANCES IN THERAPY | 2023年 / 40卷 / 11期

关键词：

Adolescents; Childhood; Incidence; Management; Pediatric; Treatment; Type; 2; diabetes; Youth-onset; BETA-CELL FUNCTION; INSULIN SENSITIVITY; GLYCEMIC CONTROL; YOUNG-ADULTS; LIFE-STYLE; YOUTH; MORTALITY; SEARCH; ROSIGLITAZONE; COMPLICATIONS;

D O I：

10.1007/s12325-023-02642-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients.

引用

页码：4711 / 4720

页数：10

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