Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences

被引：13

作者：

Kavsak, Peter A. ^{[1
]}

Clark, Lorna ^{[1
]}

Arnoldo, Saranya ^{[2
]}

Lou, Amy ^{[3
]}

Shea, Jennifer L. ^{[4
]}

Eintracht, Shaun ^{[5
]}

Lyon, Andrew W. ^{[6
]}

Bhayana, Vipin ^{[7
]}

Thorlacius, Laurel ^{[8
]}

Raizman, Joshua E. ^{[9
]}

Tsui, Albert K. Y. ^{[9
]}

Djiana, Rose ^{[5
]}

Chen, Michael ^{[10
]}

Huang, Yun

Booth, Ronald A. ^{[11
]}

McCudden, Chris ^{[11
]}

Lavoie, Joel ^{[12
]}

Beriault, Daniel R. ^{[2
]}

Blank, David W. ^{[5
]}

Fung, Angela W. S. ^{[10
]}

Hoffman, Barry ^{[2
]}

Taher, Jennifer

St-Cyr, Julie ^{[5
]}

Yip, Paul M.

Belley-Cote, Emilie P. ^{[1
,13
]}

Abramson, Beth L. ^{[2
]}

Borgundvaag, Bjug ^{[2
]}

Friedman, Steven M. ^{[2
]}

Mak, Susanna ^{[2
]}

McLaren, Jesse ^{[2
]}

Steinhart, Brian ^{[2
]}

Udell, Jacob A. ^{[2
]}

Wijeysundera, Harindra C. ^{[2
]}

Atkinson, Paul ^{[3
]}

Campbell, Samuel G. ^{[3
]}

Chandra, Kavish ^{[3
]}

Cox, Jafna L. ^{[3
]}

Mulvagh, Sharon ^{[3
]}

Quraishi, Ata-ur-Rehman ^{[3
]}

Chen-Tournoux, Annabel ^{[5
]}

Clark, Gregory ^{[5
]}

Segal, Eli ^{[5
]}

Suskin, Neville ^{[7
]}

Johri, Amer M.

Sivilotti, Marco L. A.

Garuba, Habibat ^{[11
]}

Thiruganasambandamoorthy, Venkatesh ^{[11
]}

Robinson, Simon ^{[10
,11
]}

Scheuermeyer, Frank ^{[10
]}

Humphries, Karin H.

机构：

[1] McMaster Univ, Hamilton, ON, Canada

[2] Univ Toronto, Toronto, ON, Canada

[3] Dalhousie Univ, Halifax, NS, Canada

[4] St Johns Hosp, Dept Lab Med, St John, NB, Canada

[5] McGill Univ, Montreal, PQ, Canada

[6] Univ Saskatchewan, Saskatoon, SK, Canada

[7] Western Univ, London, ON, Canada

[8] Univ Manitoba, Winnipeg, MB, Canada

[9] Univ Alberta, Fac Med & Dent, Dept Lab Med, Coll Hlth Sci, Edmonton, AB, Canada

[10] Univ British Columbia, Vancouver, BC, Canada

[11] Univ Ottawa, Ottawa, ON, Canada

[12] Inst Cardiol Montreal, Montreal, PQ, Canada

[13] Populat Hlth Res Inst, Hamilton, ON, Canada

[14] Christchurch Hosp, Dept Emergency Med, Christchurch, New Zealand

[15] Univ Otago, Dept Med, Christchurch, New Zealand

[16] Univ Edinburgh, BHF Ctr Cardiovascular Sci, Edinburgh, Midlothian, Scotland

[17] Mayo Clin & Med Ctr, Rochester, MN USA

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2023年 / 39卷 / 07期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.cjca.2023.04.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A multicentre prospective observational study (36 sites in 8 Canadian provinces), imbedded in the CODE-MI trial, had clinical laboratories at these sites test 3 samples (normal, female 99th-percentile, and male 99th-percentile concentrations) monthly for 1 year on 67 instruments, producing 2142 results from 6 distinct troponin assays. Mean differences varied per assay with maximum values being & PLUSMN; 4, & PLUSMN; 8, and & PLUSMN; 9 ng/L for the normal, female 99th-percentile, and male 99th-percentile sample, respectively. Using a pragmatic approach, combining all assays, the maximum analytic result variation was & PLUSMN; 3 ng/L for target concentrations less than 10 ng/L and & PLUSMN; 30% at concen-trations slightly above.

引用

页码：947 / 951

页数：5

共 5 条

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