A multi-omics perspective of CAR T cell therapy

被引：5
|
作者：
Yang, Jingwen [1 ]
Chen, Yamei [1 ]
Han, Leng [1 ,2 ]
机构：
[1] Texas A&M Univ, Inst Biosci & Technol, Ctr Epigenet & Dis Prevent, Houston, TX 77030 USA
[2] Texas A&M Univ, Coll Med, Dept Translat Med Sci, Houston, TX 77030 USA
来源：
CLINICAL AND TRANSLATIONAL MEDICINE | 2023年 / 13卷 / 05期
基金：
美国国家卫生研究院;
关键词：
CART; Omics;
D O I：
10.1002/ctm2.1274
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
As omics technologies, including genomics, epigenomics, transcriptomics, T cell receptor-repertorie profiling, proteomics, metabolomics and microbiomics, have provided valuable insights into CAR T cell therapy, in our recent review, we discuss these multidimensional profiling technologies in CAR T cell research, and their potential to identify tumor-specific antigens and molecular characteristics associated with anti-tumour effects and toxicities.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Advancing CAR T cell therapy through the use of multidimensional omics data
    Jingwen Yang
    Yamei Chen
    Ying Jing
    Michael R. Green
    Leng Han
    Nature Reviews Clinical Oncology, 2023, 20 : 211 - 228
  • [22] Multi-OMICS: a critical technical perspective on integrative lipidomics approaches
    Kopczynski, Dominik
    Coman, Cristina
    Zahedi, Rene P.
    Lorenz, Kristina
    Sickmann, Albert
    Ahrends, Robert
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2017, 1862 (08): : 808 - 811
  • [23] Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies
    Daliri, Eric Banan-Mwine
    Ofosu, Fred Kwame
    Chelliah, Ramachandran
    Lee, Byong H.
    Oh, Deog-Hwan
    BIOMOLECULES, 2021, 11 (02) : 1 - 10
  • [24] Multi-omics research strategies in ischemic stroke: A multidimensional perspective
    Li, Wentao
    Shao, Chongyu
    Zhou, Huifen
    Du, Haixia
    Chen, Haiyang
    Wan, Haitong
    He, Yu
    AGEING RESEARCH REVIEWS, 2022, 81
  • [25] Advancing CAR T cell therapy through the use of multidimensional omics data
    Yang, Jingwen
    Chen, Yamei
    Jing, Ying
    Green, Michael R.
    Han, Leng
    NATURE REVIEWS CLINICAL ONCOLOGY, 2023, 20 (04) : 211 - 228
  • [26] Are multi-omics enough?
    Vilanova, Cristina
    Porcar, Manuel
    NATURE MICROBIOLOGY, 2016, 1 (08)
  • [27] CLINICAL MULTI-OMICS
    Radstake, Timothy R.
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 16 - 16
  • [28] Multi-omics perspective on studying reproductive biology in Daphnia sinensis
    Jia, Jingyi
    Dong, Chenchen
    Han, Mengqi
    Ma, Siqi
    Chen, Wenkai
    Dou, Jun
    Feng, Cui
    Liu, Xiangjiang
    GENOMICS, 2022, 114 (02)
  • [29] Defining NASH from a Multi-Omics Systems Biology Perspective
    Niu, Lili
    Sulek, Karolina
    Vasilopoulou, Catherine G.
    Santos, Alberto
    Wewer Albrechtsen, Nicolai J.
    Rasmussen, Simon
    Meier, Florian
    Mann, Matthias
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (20)
  • [30] A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine
    Ye, Youqiong
    Zhang, Zhao
    Liu, Yaoming
    Diao, Lixia
    Han, Leng
    TRENDS IN GENETICS, 2020, 36 (05) : 318 - 336
12345