Phylogenetic and epidemiological characteristics of H9N2 avian influenza viruses in Shandong Province, China from 2019 to 2021

被引：3

作者：

Zhao, Yi-ran ^{[1
]}

Zhao, Yu-zhong ^{[1
]}

Liu, Si-dang ^{[1
]}

Xiao, Yi-hong ^{[1
]}

Li, Ning ^{[1
]}

Liu, Kui-hao ^{[1
]}

Meng, Fan-liang ^{[1
]}

Zhao, Jun ^{[1
]}

Liu, Meng-da ^{[2
]}

Li, Bao-quan ^{[1
]}

机构：

[1] Shandong Agr Univ, Shandong Agr Univ, Coll Anim Sci & Vet Med, Shandong Prov Key Lab Anim Biotechnol & Dis Contro, Tai An 271018, Peoples R China

[2] China Anim Hlth & Epidemiol Ctr, Div Zoonoses Surveillance, RChina, Qingdao 266033, Peoples R China

来源：

JOURNAL OF INTEGRATIVE AGRICULTURE | 2023年 / 22卷 / 03期

关键词：

influenza virus; phylogenetic analyses; mutation sites; pathogenicity; antibody titer; epidemiological surveillance; MOLECULAR CHARACTERIZATION; GENETIC-CHARACTERIZATION; A VIRUS; HEMAGGLUTININ; EVOLUTION; POULTRY; SUBTYPE; SURVEILLANCE; REPLICATION; RESISTANT;

D O I：

10.1016/j.jia.2022.08.114

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

H9N2 avian influenza virus (AIV) has widely circulated in poultry worldwide and sporadic infections in humans and mammals. During our surveillance of chicken from 2019 to 2021 in Shandong Province, China, we isolated 11 H9N2 AIVs. Phylogenetic analyses showed that the eight gene segments of the 11 isolates were closely related to several sublineages of Eurasian lineage: BJ/94-like clades (HA and NA genes), G1-like clades (PB2 and M genes), and SH/ F/98-like clades (PB1, PA, NP and NS genes). The isolates showed mutation sites that preferentially bind to human-like receptors (HA) and mammalian fitness sites (PB2, PB1 and PA), as well as mutations in antigen and drug resistance sites. Moreover, studies with mice revealed four isolates with varying levels of pathogenicity. The average antibody titer of the H9N2 AIVs was 8.60 log2. Based on our results, the epidemiological surveillance of H9N2 AIVs should be

引用

页码：881 / 896

页数：16

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