One-pot multi-component synthesis and cytotoxic activity of terpenoid dimers containing azapolycyclic spacers

被引：0

作者：

Rakhimova, Elena B. ^{[1
]}

Kirsanov, Victor Yu. ^{[1
]}

Kuzmina, Ulyana Sh. ^{[2
]}

Vakhitova, Yulia V. ^{[2
]}

机构：

[1] Russian Acad Sci, Ufa Fed Res Ctr, Inst Petrochemistry & Catalysis, Ufa 450075, Russia

[2] Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa 450054, Russia

来源：

MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 01期

关键词：

heterocyclization; maleopimaric acid; terpenoids; zeolite; polycycles; cytotoxic activity; CATALYTIC SYNTHESIS; ANTITUMOR-ACTIVITY; DERIVATIVES;

D O I：

10.1016/j.mencom.2023.01.020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel terpenoid dimers linked through the E-E rings were synthesized by catalytic multicomponent condensation of amino derivatives of methyl maleopimarate with form-aldehyde and dimethyl-tetraazadecalin or tetraazaperhydro-tetracene. Primary screening of the synthesized terpenoid dimers for cytotoxic activity was performed.

引用

页码：64 / 66

页数：3

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