Tandem autologous stem cell transplantation in elderly patients with myeloma: A multicenter retrospective analysis

被引：2

作者：

Suzuki, Kazuhito ^{[1
,2
]}

Mizuno, Shohei ^{[3
]}

Shimazu, Yutaka ^{[4
]}

Fuchida, Shin-ichi ^{[5
]}

Hagiwara, Shotaro ^{[6
]}

Itagaki, Mitsuhiro ^{[7
]}

Nishiwaki, Kaichi ^{[2
]}

Hangaishi, Akira ^{[8
]}

Karasuno, Takahiro ^{[9
]}

Kikuchi, Taku ^{[10
]}

Shimizu, Misayo ^{[11
]}

Nishikawa, Akinori ^{[12
]}

Kobayashi, Takeshi ^{[13
]}

Sunami, Kazutaka ^{[14
]}

Hiramoto, Nobuhiro ^{[15
]}

Uchiyama, Hitoji ^{[16
]}

Maruyama, Yumiko ^{[17
]}

Kanda, Yoshinobu ^{[18
]}

Ichinohe, Tatsuo ^{[19
]}

Atsuta, Yoshiko ^{[20
,21
]}

Yano, Shingo ^{[2
]}

Kawamura, Koji ^{[22
]}

机构：

[1] Jikei Univ, Kashiwa Hosp, Dept Internal Med, Div Clin Oncol Hematol, Kashiwa, Japan

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Clin Oncol Hematol, Kashiwa, Japan

[3] Aichi Med Univ, Dept Internal Med, Div Hematol, Nagakute, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[5] Japan Community Hlth Care Org, Kyoto Kuramaguchi Med Ctr, Dept Hematol, Kyoto, Japan

[6] Tsukuba Univ Hosp, Mito Clin Educ & Training Ctr, Div Hematol, Tsukuba, Japan

[7] Hiroshima Red Cross Hosp & Atom Bomb Survivors Ho, Dept Hematol, Hiroshima, Japan

[8] Natl Ctr Global Hlth & Med, Dept Hematol, Tokyo, Japan

[9] Rinku Gen Med Ctr, Div Hematol, Izumisano, Japan

[10] Keio Univ, Sch Med, Dept Med, Div Hematol, Tokyo, Japan

[11] Hitachi Ltd, Hitachi Gen Hosp, Dept Hematol & Oncol, Hitachi, Japan

[12] Wakayama Med Univ, Dept Hematol Oncol, Wakayama, Japan

[13] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[14] Natl Hosp Org Okayama Med Ctr, Dept Hematol, Okayama, Japan

[15] Kobe City Med Ctr Gen Hosp, Dept Hematol, Kobe, Japan

[16] Japanese Red Cross Kyoto Daiichi Hosp, Dept Hematol, Kyoto, Japan

[17] Univ Tsukuba Hosp, Dept Hematol, Tsukuba, Japan

[18] Jichi Med Univ, Div Hematol, Shimotsuke, Japan

[19] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[20] Japanese Data Ctr Hematopoiet Cell Transplantat, Aichi, Japan

[21] Aichi Med Univ, Sch Med, Dept Registry Sci Transplant & Cellular Therapy, Aichi, Japan

[22] Tottori Univ, Fac Med, Dept Multidisciplinary Internal Med, Div Clin Lab Med, Tottori, Japan

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2023年 / 110卷 / 04期

关键词：

elderly; high-risk cytogenetic abnormality; multiple myeloma; safety; tandem autologous stem cell transplantation; DIAGNOSED MULTIPLE-MYELOMA; LENALIDOMIDE MAINTENANCE; OPEN-LABEL; PREDNISONE; BORTEZOMIB; SURVIVAL; THERAPY; SINGLE; DEXAMETHASONE; MELPHALAN;

D O I：

10.1111/ejh.13922

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tandem autologous stem cell transplantation (ASCT) has been reconsidered for high-risk patients with myeloma, and the eligibility criteria for up-front ASCT have been updated to include more elderly patients. This study aimed to evaluate the efficacy and tolerability of tandem ASCT in elderly patients with myeloma compared to tandem ASCT in young patients and single ASCT in elderly patients. A retrospective study using the Transplant Registry Unified Management Program database of the Japanese Society for Transplantation and Cellular Therapy, which included 64 elderly and 613 young patients who received tandem ASCT, and 891 elderly patients who received single ASCT, was conducted. The median overall survival (OS) over 38.5 months in the elderly and young patients who received tandem ASCT, and elderly patients who received single ASCT was 78.9, 92.5, and 77.1 months, respectively; no significant difference in the median OS was observed. The cumulative incidence of transplantation-related mortality was similar in the elderly and young patients receiving tandem ASCT. High-risk cytogenetic abnormality was not identified as a poor prognostic factor for OS in elderly patients who received tandem ASCT but in those who received single ASCT. Thus, tandem ASCT was effective and tolerable in elderly patients with myeloma.

引用

页码：444 / 454

页数：11

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