Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

被引：4

作者：

Makris, Georgios ^{[1
,2
,3
]}

Kayhan, Semih ^{[1
,2
]}

Kreuzer, Marvin ^{[4
]}

Rufenacht, Veronique ^{[1
,2
]}

Faccin, Erica ^{[4
]}

Underhaug, Jarl ^{[5
,6
]}

Diez-Fernandez, Carmen ^{[1
,2
,7
]}

Knobel, Philip A. ^{[4
,8
]}

Poms, Martin ^{[9
]}

Gougeard, Nadine ^{[10
]}

Rubio, Vicente ^{[10
]}

Martinez, Aurora ^{[5
]}

Pruschy, Martin ^{[4
]}

Haberle, Johannes ^{[1
,2
]}

机构：

[1] Univ Zurich, Univ Childrens Hosp Zurich, Div Metab, Zurich, Switzerland

[2] Univ Zurich, Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland

[3] Univ Zurich, Ctr Integrat Human Physiol, Zurich, Switzerland

[4] Univ Zurich, Univ Hosp Zurich, Dept Radiat Oncol, Lab Appl Radiobiol, Zurich, Switzerland

[5] Univ Bergen, Dept Biomed, Bergen, Norway

[6] Univ Bergen, Dept Chem, Bergen, Norway

[7] NUVISAN GmbH, Neu Ulm, Bavaria, Germany

[8] CDR Life Inc, Zurich, Switzerland

[9] Univ Zurich, Univ Childrens Hosp Zurich, Div Clin Chem & Biochem, Zurich, Switzerland

[10] CIBER Enfermedades Raras CIBERER ISCIII, Inst Biomed Valencia IBV CSIC, Valencia, Spain

来源：

CANCER COMMUNICATIONS | 2023年 / 43卷 / 04期

关键词：

D O I：

10.1002/cac2.12402

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：508 / 512

页数：5

共 10 条

[1] The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics [J].

Guillouzo, Andre ;

Corlu, Anne ;

Aninat, Caroline ;

Glaise, Denise ;

Morel, Fabrice ;

Guguen-Guillouzo, Christiane .

CHEMICO-BIOLOGICAL INTERACTIONS, 2007, 168 (01) :66-73

[2] Mechanisms and Implications of Metabolic Heterogeneity in Cancer [J].

Kim, Jiyeon ;

DeBerardinis, Ralph J. .

CELL METABOLISM, 2019, 30 (03) :434-446

[3] CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells [J].

Kim, Jiyeon ;

Hu, Zeping ;

Cai, Ling ;

Li, Kailong ;

Choi, Eunhee ;

Faubert, Brandon ;

Bezwada, Divya ;

Rodriguez-Canales, Jaime ;

Villalobos, Pamela ;

Lin, Yu-Fen ;

Ni, Min ;

Huffman, Kenneth E. ;

Girard, Luc ;

Byers, Lauren A. ;

Unsal-Kacmaz, Keziban ;

Pena, Christopher G. ;

Heymach, John V. ;

Wauters, Els ;

Vansteenkiste, Johan ;

Castrillon, Diego H. ;

Chen, Benjamin P. C. ;

Wistuba, Ignacio ;

Lambrechts, Diether ;

Xu, Jian ;

Minna, John D. ;

DeBerardinis, Ralph J. .

NATURE, 2017, 546 (7656) :168-+

[4] Predictors of Response, Progression-Free Survival, and Overall Survival in Patients With Lung Cancer Treated With Immune Checkpoint Inhibitors [J].

Memmott, Regan M. ;

Wolfe, Adam R. ;

Carbone, David P. ;

Williams, Terence M. .

JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (07) :1086-1098

[5]

PIERSON DL, 1980, J BIOL CHEM, V255, P7891

[6]

Ratner S., 1976, THE UREA CYCLE, P181

[7] Metabolomics in cancer research and emerging applications in clinical oncology [J].

Schmidt, Daniel R. ;

Patel, Rutulkumar ;

Kirsch, David G. ;

Lewis, Caroline A. ;

Vander Heiden, Matthew G. ;

Locasale, Jason W. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2021, 71 (04) :333-358

[8] Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities [J].

Skoulidis, Ferdinandos ;

Byers, Lauren A. ;

Diao, Lixia ;

Papadimitrakopoulou, Vassiliki A. ;

Tong, Pan ;

Izzo, Julie ;

Behrens, Carmen ;

Kadara, Humam ;

Parra, Edwin R. ;

Canales, Jaime Rodriguez ;

Zhang, Jianjun ;

Giri, Uma ;

Gudikote, Jayanthi ;

Cortez, Maria A. ;

Yang, Chao ;

Fan, Youhong ;

Peyton, Michael ;

Girard, Luc ;

Coombes, Kevin R. ;

Toniatti, Carlo ;

Heffernan, Timothy P. ;

Choi, Murim ;

Frampton, Garrett M. ;

Miller, Vincent ;

Weinstein, John N. ;

Herbst, Roy S. ;

Wong, Kwok-Kin ;

Zhang, Jianhua ;

Sharma, Padmanee ;

Mills, Gordon B. ;

Hong, Waun K. ;

Minna, John D. ;

Allison, James P. ;

Futreal, Andrew ;

Wang, Jing ;

Wistuba, Ignacio I. ;

Heymach, John V. .

CANCER DISCOVERY, 2015, 5 (08) :860-877

[9] Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies [J].

Walsh, Robert J. ;

Soo, Ross A. .

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020, 12

[10] Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket [J].

Yao, Shihua ;

Tuong-Vi Nguyen ;

Rolfe, Alan ;

Agrawal, Anant A. ;

Ke, Jiyuan ;

Peng, Shouyong ;

Colombo, Federico ;

Yu, Sean ;

Bouchard, Patricia ;

Wu, Jiayi ;

Huang, Kuan-Chun ;

Bao, Xingfeng ;

Omoto, Kiyoyuki ;

Selvaraj, Anand ;

Yu, Lihua ;

Ioannidis, Stephanos ;

Vaillancourt, Frederic H. ;

Zhu, Ping ;

Larsen, Nicholas A. ;

Bolduc, David M. .

CELL CHEMICAL BIOLOGY, 2020, 27 (03) :259-+

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