Antifungal polyketides from the marine-derived fungus Nigrospora sp. MG36-1

被引：0

作者：

Lan, Donghe ^{[1
]}

Ge, Yichao ^{[1
]}

Zhou, Chengzeng ^{[1
]}

Li, Sihui ^{[1
]}

Wang, Jingyu ^{[1
]}

Wu, Xiaodan ^{[2
]}

Zhang, Xiaoqin ^{[3
]}

Lei, Houxing ^{[3
]}

Wu, Bin ^{[1
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Zhoushan 321000, Peoples R China

[2] Zhejiang Univ, Ctr Anal, Hangzhou 310058, Peoples R China

[3] Lishui Hosp Tradit Chinese Med, Zhejiang Prov Key Lab Inheritance & Innovat She Me, Lishui 323000, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

关键词：

Griseofulvin derivative; Hydroanthraquinone; Nigrospora sp; Antifungal activity; GRISEOFULVIN; METABOLITES; DERIVATIVES; ORYZAE;

D O I：

10.1016/j.fitote.2022.105406

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new polyketides, a griseofulvin derivative 1, a hydroanthraquinone derivative 8 and a pyranolactone derivative 10, together with eight known compounds (2-7, 9 and 11), were isolated from the marine-derived fungus Nigrospora sp. MG36-1. The structures of the three new compounds were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, 13C NMR calculation in combination with DP4+ and ECD calculations. The antitumor, antibacterial and antifungal activities of the compounds 1-9 were evaluated in vitro. Compound 1 showed antibacterial activity against Acinetobacter baumannii with MIC 42.5 mu g/mL. Com-pounds 1 and 8 exhibited antifungal activity against Candida albicans with MICs 21.5 mu g/mL and 17.5 mu g/mL, respectively.

引用

页数：6

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