Acute toxic effects of new synthetic cannabinoid on brain: Neurobehavioral and Histological: Preclinical studies

被引：18

作者：

Ali, Shrouk Mohamed ^{[1
]}

Kolieb, Eman ^{[2
]}

Imbaby, Samar ^{[3
]}

Hagras, Abeer M. ^{[1
]}

Arafat, Horeya Erfan Korayem ^{[4
]}

Kamel, Eman Mohamed ^{[5
]}

Abdelshakour, Mohamed A. ^{[6
]}

Ali, Maha Ismail Mohammed ^{[1
]}

机构：

[1] Suez Canal Univ, Fac Med, Forens Med & Clin Toxicol Dept, Ismailia 41522, Egypt

[2] Suez Canal Univ, Fac Med, Med Physiol Dept, Ismailia 41522, Egypt

[3] Suez Canal Univ, Fac Med, Clin Pharmacol Dept, Ismailia 41522, Egypt

[4] Suez Canal Univ, Fac Med, Histol & Cell Biol Dept, Ismailia 41522, Egypt

[5] Suez Canal Univ, Fac Med, Human Anat & Embryol Dept, Ismailia 41522, Egypt

[6] Sohag Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Sohag 82524, Egypt

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2023年 / 370卷

关键词：

Synthetic cannabinoids; MDMB-4en-PINACA; Behavioral studies; Neurotransmitters; GLUTAMATERGIC SYNAPSES; LOCOMOTOR-ACTIVITY; JWH-018; RAT; NEUROTOXICITY; ACTIVATION; MECHANISMS; IMPAIRS; SYSTEM; KINASE;

D O I：

10.1016/j.cbi.2022.110306

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The psychoactive effects of new synthetic cannabinoids (SCs), MDMB-4en-PINACA, are being marketed as a blend of herbs and spices. This study aims to determine the behavioral, neurochemical, histopathological, and immunohistochemical alterations associated with the acute toxicity of MDMB-4en-PINACA compounds. Methods: Adult male albino rats were administered various toxic doses of the drug (1.5, 3, and 6 mg/kg), and behavioral studies were conducted 2 and 24 h later; animals were then sacrificed. Histopathological and neurochemical examinations were performed. Two hours after intraperitoneal. Results: Intraperitoneal injection of MDMB-4en-PINACA, horizontal movement, the number of stops, and mobility ratio were significantly impaired, along with coordination and balance. In addition, it led to a decline in spatial learning and memory, and neurotransmitter concentrations decreased significantly in a dose-dependent manner. Further examination of the cerebral cortex and hippocampus histopathology revealed pathological degeneration of small pyramidal cells. Conclusion: Thus, these findings revealed that MDMB-4en-PINACA interferes with hippocampal function and impairs cognitive performance, highlighting the cognitive risk associated with SC abuse.

引用

页数：13

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