Integrated large-scale solid waste management (SWM) policies are the need of the hour to design, develop and sustain SWM models. An accurate prediction and forecasting of municipal solid waste generation (MSWG) rate are essential for such advanced strategies. The primary objective of this study is to examine the criticality of demographic and socio-economic parameters for the fair prediction and forecasting of the MSWG rate. Machine learning (ML) models were formulated by mapping solid waste quantities at the municipal level with socio-economic and demographic variables of Guwahati city. Tree-based ML algorithms, namely decision tree (DT), random forest (RF) and gradient boosting (GB), were applied to build the models with 1936 data size. The moving average (MA) approaches were adapted for the forecasting of the MSWG rate. Model validation resulted in a root mean square error, RMSE (3.01), mean absolute error, MAE (2.86) and coefficient of determination, R-2 (0.99) for the GB model and correlation coefficient (r) of 0.82 between observed and predicted values and thereby resulted in best performance in conjunction with DT and RF. With the exponential MA, the forecasted RMSE and R-2 for GB, RF and DT were 2.12, 3.63 and 4.22; and 0.981, 0.972 and 0.967, respectively. However, with a model accuracy of 97%, the computation time for GB model (19.18 min) exhibited maximum due to its high complexity. The overall methodology involved developing effective tools to aid in regional SWM and planning through the integration of data sources in the public domain, pre-processing and modelling from diverse sources.