Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota

被引：4

作者：

Murata, Midori ^{[1
]}

Shoda, Asuka ^{[1
]}

Kimura, Mako ^{[1
]}

Hara, Yukako ^{[1
]}

Yonoichi, Sakura ^{[1
]}

Ishida, Yuya ^{[1
]}

Mantani, Youhei ^{[2
]}

Yokoyama, Toshifumi ^{[1
]}

Matsuo, Eiko ^{[3
]}

Hirano, Tetsushi ^{[4
]}

Hoshi, Nobuhiko ^{[1
,5
]}

机构：

[1] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Anim Mol Morphol, Kobe, Hyogo, Japan

[2] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Histophysiol, Kobe, Hyogo, Japan

[3] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Microbiol & Immunol, Kobe, Hyogo, Japan

[4] Univ Toyama, Life Sci Res Ctr, Toyama, Japan

[5] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Anim Mol Morphol, 1-1 Rokkodai, Nada, Kobe, Hyogo 6578501, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2023年 / 85卷 / 04期

基金：

日本学术振兴会;

关键词：

clothianidin; dysbiosis; fetal and lactational exposure; Hassall's corpuscles; thymus; REGULATORY T-CELLS; HASSALLS CORPUSCLES; RECEPTOR; DIFFERENTIATION; INFLAMMATION; DINOTEFURAN; MECHANISMS; EXPRESSION; STRESS; HEALTH;

D O I：

10.1292/jvms.23-0038

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Recently, the effects of exposure to clothianidin (CLO) on the thymus and gut microbiota have become clear, but no report has examined its next-generation impacts. Pregnant C57BL/6N mice were administered a no-observed-adverse-effect-level dose of CLO until weaning. We examined CLO's effects on the gut microbiota and immune organs of dams and their 3-and 10-week-old male offspring. CLO administration led to several alterations of the top 30 bacterial genera in the gut microbiota in dams and 3-week-old mice. Compared to controls, 10-week-old mice had more thymic Hassall's corpuscles, and both dams and 10-week-old mice had fewer macrophages. These results suggest that fetal and lactational CLO exposure may affect the immune system and gut microbiota of the next generation.

引用

页码：434 / 442

页数：9

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