What the BTBR/J mouse has taught us about diabetes and diabetes complications

被引：4

作者：

Keller, Mark P. ^{[1
]}

Hudkins, Kelly L. ^{[2
]}

Shalev, Anath ^{[3
]}

Bhatnagar, Sushant ^{[3
]}

Kebede, Melkam A. ^{[6
]}

Merrins, Matthew J. ^{[4
,5
]}

Davis, Dawn B. ^{[4
,5
]}

Alpers, Charles E. ^{[2
]}

Kimple, Michelle E. ^{[4
,5
]}

Attie, Alan D. ^{[1
,4
,7
]}

机构：

[1] Univ Wisconsin Madison, Dept Biochem, Madison, WI 53706 USA

[2] Univ Washington, Dept Pathol, Med Ctr, Seattle, WA 98195 USA

[3] Univ Alabama Birmingham, Dept Med, Div Endocrinol Diabet & Metab, Birmingham, AL 35294 USA

[4] Univ Wisconsin, Dept Med, Div Endocrinol Diabet & Metab, Sch Med & Publ Hlth, Madison, WI 53705 USA

[5] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA

[6] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sch Med Sci, Sydney 2006, Australia

[7] Univ Wisconsin Madison, Dept Chem, Madison, WI 53706 USA

来源：

ISCIENCE | 2023年 / 26卷 / 07期

基金：

英国科研创新办公室;

关键词：

THIOREDOXIN-INTERACTING PROTEIN; QUANTITATIVE TRAIT LOCUS; BETA-CELL; GENE-EXPRESSION; KIDNEY-DISEASE; INSULIN HYPERSECRETION; POSITIONAL CLONING; CANDIDATE GENE; OB/OB MICE; MODEL;

D O I：

10.1016/j.isci.2023.107036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model. © 2023 The Author(s)

引用

页码：1 / +

页数：32

共 26 条

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