The Utility of ctDNA in Lung Cancer Clinical Research and Practice: A Systematic Review and Meta-Analysis of Clinical Studies

被引：6

作者：

Sun, Xuezheng ^{[1
,8
]}

Abrahamson, Page ^{[2
]}

Ballew, Nicholas ^{[3
]}

Kalilani, Linda ^{[1
]}

Phiri, Kelesitse ^{[3
]}

Bell, Kelly F. ^{[3
]}

Slowley, Alexander ^{[4
]}

Zajac, Magdalena ^{[4
]}

Hofstatter, Erin ^{[5
]}

Stojadinovic, Alexander ^{[3
]}

Silvestro, Angela ^{[5
]}

Wang, Zebin ^{[5
]}

Aziez, Amine ^{[6
]}

Peters, Solange ^{[7
]}

机构：

[1] GSK, Res Triangle Pk, NC USA

[2] Salmon Bay Consulting, Seattle, WA USA

[3] GSK, Collegeville, PA USA

[4] GSK, London, England

[5] GSK, Waltham, MA USA

[6] GSK, Zug, Switzerland

[7] Lausanne Univ Hosp, Dept Oncol, Lausanne, Switzerland

[8] GSK, Oncol Epidemiol Value Evidence & Outcomes, R&D Global Med, 5 Moore Dr, Res Triangle Pk, NC 27709 USA

来源：

CANCER INVESTIGATION | 2023年 / 41卷 / 06期

关键词：

Biomarker; circulating tumor DNA; non-small cell lung cancer; small cell lung cancer; lung cancer; CIRCULATING TUMOR DNA; TYROSINE KINASE INHIBITORS; CELL-FREE DNA; ADVANCED NSCLC PATIENTS; EGFR MUTATIONS; LIQUID BIOPSY; TARGETED THERAPY; DYNAMIC CHANGES; PLASMA; ADENOCARCINOMA;

D O I：

10.1080/07357907.2023.2220820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase database search, 111 studies from 2015 to 2020 demonstrated ctDNA's value in prognostication/monitoring disease progression, mainly in patients with advanced/metastatic disease and non-small cell lung cancer. ctDNA positivity/detection at any time point was associated with shorter progression-free survival and overall survival, whereas ctDNA clearance/decrease during treatment was associated with a lower risk of progression and death. Validating these findings and addressing challenges regarding ctDNA testing integration into clinical practice will require further research.

引用

页码：571 / 592

页数：22

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