The Utility of ctDNA in Lung Cancer Clinical Research and Practice: A Systematic Review and Meta-Analysis of Clinical Studies

被引：6

作者：

Sun, Xuezheng ^{[1
,8
]}

Abrahamson, Page ^{[2
]}

Ballew, Nicholas ^{[3
]}

Kalilani, Linda ^{[1
]}

Phiri, Kelesitse ^{[3
]}

Bell, Kelly F. ^{[3
]}

Slowley, Alexander ^{[4
]}

Zajac, Magdalena ^{[4
]}

Hofstatter, Erin ^{[5
]}

Stojadinovic, Alexander ^{[3
]}

Silvestro, Angela ^{[5
]}

Wang, Zebin ^{[5
]}

Aziez, Amine ^{[6
]}

Peters, Solange ^{[7
]}

机构：

[1] GSK, Res Triangle Pk, NC USA

[2] Salmon Bay Consulting, Seattle, WA USA

[3] GSK, Collegeville, PA USA

[4] GSK, London, England

[5] GSK, Waltham, MA USA

[6] GSK, Zug, Switzerland

[7] Lausanne Univ Hosp, Dept Oncol, Lausanne, Switzerland

[8] GSK, Oncol Epidemiol Value Evidence & Outcomes, R&D Global Med, 5 Moore Dr, Res Triangle Pk, NC 27709 USA

来源：

CANCER INVESTIGATION | 2023年 / 41卷 / 06期

关键词：

Biomarker; circulating tumor DNA; non-small cell lung cancer; small cell lung cancer; lung cancer; CIRCULATING TUMOR DNA; TYROSINE KINASE INHIBITORS; CELL-FREE DNA; ADVANCED NSCLC PATIENTS; EGFR MUTATIONS; LIQUID BIOPSY; TARGETED THERAPY; DYNAMIC CHANGES; PLASMA; ADENOCARCINOMA;

D O I：

10.1080/07357907.2023.2220820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase database search, 111 studies from 2015 to 2020 demonstrated ctDNA's value in prognostication/monitoring disease progression, mainly in patients with advanced/metastatic disease and non-small cell lung cancer. ctDNA positivity/detection at any time point was associated with shorter progression-free survival and overall survival, whereas ctDNA clearance/decrease during treatment was associated with a lower risk of progression and death. Validating these findings and addressing challenges regarding ctDNA testing integration into clinical practice will require further research.

引用

页码：571 / 592

页数：22

共 142 条

[1] Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution [J].

Abbosh, Christopher ;

Birkbak, Nicolai J. ;

Wilson, Gareth A. ;

Jamal-Hanjani, Mariam ;

Constantin, Tudor ;

Salari, Raheleh ;

Le Quesne, John ;

Moore, David A. ;

Veeriah, Selvaraju ;

Rosenthal, Rachel ;

Marafioti, Teresa ;

Kirkizlar, Eser ;

Watkins, Thomas B. K. ;

McGranahan, Nicholas ;

Ward, Sophia ;

Martinson, Luke ;

Riley, Joan ;

Fraioli, Francesco ;

Al Bakir, Maise ;

Gronroos, Eva ;

Zambrana, Francisco ;

Endozo, Raymondo ;

Bi, Wenya Linda ;

Fennessy, Fiona M. ;

Sponer, Nicole ;

Johnson, Diana ;

Laycock, Joanne ;

Shafi, Seema ;

Czyzewska-Khan, Justyna ;

Rowan, Andrew ;

Chambers, Tim ;

Matthews, Nik ;

Turajlic, Samra ;

Hiley, Crispin ;

Lee, Siow Ming ;

Forster, Martin D. ;

Ahmad, Tanya ;

Falzon, Mary ;

Borg, Elaine ;

Lawrence, David ;

Hayward, Martin ;

Kolvekar, Shyam ;

Panagiotopoulos, Nikolaos ;

Janes, Sam M. ;

Thakrar, Ricky ;

Ahmed, Asia ;

Blackhall, Fiona ;

Summers, Yvonne ;

Hafez, Dina ;

Naik, Ashwini .

NATURE, 2017, 545 (7655) :446-+

[2] Circulating Tumor DNA Analysis for Patients with Oncogene-Addicted NSCLC With Isolated Central Nervous System Progression [J].

Aldea, Mihaela ;

Hendriks, Lizza ;

Mezquita, Laura ;

Jovelet, Cecile ;

Planchard, David ;

Auclin, Edouard ;

Remon, Jordi ;

Howarth, Karen ;

Benitez, Jose Carlos ;

Gazzah, Anas ;

Lavaud, Pernelle ;

Naltet, Charles ;

Lacroix, Ludovic ;

de Kievit, Frank ;

Morris, Clive ;

Green, Emma ;

Ngo-Camus, Maud ;

Rouleau, Etienne ;

Massard, Christophe ;

Caramella, Caroline ;

Friboulet, Luc ;

Besse, Benjamin .

JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (03) :383-391

[3] Total and mutated EGFR quantification in cell-free DNA from non-small cell lung cancer patients detects tumor heterogeneity and presents prognostic value [J].

Alegre, E. ;

Fusco, J. P. ;

Restituto, P. ;

Salas-Benito, D. ;

Rodriguez-Ruiz, M. E. ;

Andueza, M. P. ;

Pajares, M. J. ;

Patino-Garcia, A. ;

Pio, R. ;

Lozano, M. D. ;

Gurpide, A. ;

Lopez-Picazo, J. M. ;

Gil-Bazo, I. ;

Perez-Gracia, J. L. ;

Gonzalez, A. .

TUMOR BIOLOGY, 2016, 37 (10) :13687-13694

[4] Tumor Evolution as a Therapeutic Target [J].

Amirouchene-Angelozzi, Nabil ;

Swanton, Charles ;

Bardelli, Alberto .

CANCER DISCOVERY, 2017, 7 (08) :805-817

[5] Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer [J].

Anagnostou, Valsamo ;

Forde, Patrick M. ;

White, James R. ;

Niknafs, Noushin ;

Hruban, Carolyn ;

Naidoo, Jarushka ;

Marrone, Kristen ;

Sivakumar, I. K. Ashok ;

Bruhm, Daniel C. ;

Rosner, Samuel ;

Phallen, Jillian ;

Leal, Alessandro ;

Adleff, Vilmos ;

Smith, Kellie N. ;

Cottrell, Tricia R. ;

Rhymee, Lamia ;

Palsgrove, Doreen N. ;

Hann, Christine L. ;

Levy, Benjamin ;

Feliciano, Josephine ;

Georgiades, Christos ;

Verde, Franco ;

Illei, Peter ;

Li, Qing Kay ;

Gabrielson, Edward ;

Brock, Malcolm V. ;

Isbell, James M. ;

Sauter, Jennifer L. ;

Taube, Janis ;

Scharpf, Robert B. ;

Karchin, Rachel ;

Pardoll, Drew M. ;

Chaft, Jamie E. ;

Hellmann, Matthew D. ;

Brahmer, Julie R. ;

Velculescu, Victor E. .

CANCER RESEARCH, 2019, 79 (06) :1214-1225

[6] SOX17 promoter methylation in plasma circulating tumor DNA of patients with non-small cell lung cancer [J].

Balgkouranidou, Ioanna ;

Chimonidou, Maria ;

Milaki, Georgia ;

Tsaroucha, Emily ;

Kakolyris, Stylianos ;

Georgoulias, Vasilis ;

Lianidou, Evi .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2016, 54 (08) :1385-1393

[7] Circulating tumor DNA analysis of EGFR-mutant non-small cell lung cancer patients receiving osimertinib following previous tyrosine kinase inhibitor treatment [J].

Beagan, Jamie J. ;

Bach, Sander ;

van Boerdonk, Robert A. ;

van Dijk, Erik ;

Thunnissen, Erik ;

van den Broek, Daan ;

Weiss, Janneke ;

Kazemier, Geert ;

Pegtel, D. Michiel ;

Bahce, Idris ;

Ylstra, Bauke ;

Heideman, Danielle A. M. .

LUNG CANCER, 2020, 145 :173-180

[8] Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy [J].

Boonstra, Pieter A. ;

Wind, Thijs T. ;

van Kruchten, Michel ;

Schuuring, Ed ;

Hospers, Geke A. P. ;

van der Wekken, Anthonie J. ;

de Groot, Derk-Jan ;

Schroeder, Carolien P. ;

Fehrmann, Rudolf S. N. ;

Reyners, Anna K. L. .

CANCER AND METASTASIS REVIEWS, 2020, 39 (03) :999-1013

[9] A basic introduction to fixed-effect and random-effects models for meta-analysis [J].

Borenstein, Michael ;

Hedges, Larry V. ;

Higgins, Julian P. T. ;

Rothstein, Hannah R. .

RESEARCH SYNTHESIS METHODS, 2010, 1 (02) :97-111

[10] EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib [J].

Buder, Anna ;

Hochmair, Maximilian J. ;

Setinek, Ulrike ;

Pirker, Robert ;

Filipits, Martin .

TRANSLATIONAL LUNG CANCER RESEARCH, 2020, 9 (02) :239-+

← 1 2 3 4 5 6 7 8 9 10 →