The H-shaped steel beam is popular due to its ease of manufacturing and connection to the column. This profile, which is used as a shallow beam, needs the high weak-axis bending stiffness and torsional stiffness to meet the overall stability. Achieving the local beam flange stability, bearing capacity, bending stiffness, and torsional requirements need a great thickness and width of the beam flange, which causes, which will cause more uneconomical structural design. So, the box-section beam is the ideal alternative. However, the current design specifications do not have design rules for the bolt-and-welded connection of the box-section beam and box-section column. The paper proposes a novel bolt-and-welded connection of the box-section beams and box-section columns based on a high-rise structural design scheme. Three connection models, BASE, WBF, and RBS, are analyzed under cyclic loading in ABAQUS software. The failure modes, hysteresis response, bearing capacity, ductility, plastic rotation angle, energy dissipation, and stiffness degradation of all models are determined and compared. Compared with the other two models, the model WBF exhibited excellent seismic performance, ductility, and plastic rotation ability. Finally, model WBF was chosen as the connection scheme used in the project design.