Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Asparagus against Glioblastoma

Glioblastoma (GBM) is the most malignant primary brain tumor, and there is an urgent need to explore effective therapeutic strategies to improve the prognosis of GBM patients. Asparagus (ASP) is a widely grown plant with a rich pharmacological profile that has been used to treat various cancers. However, its role in GBM remains unclear. In the study, we confirmed the inhibitory effect of ASP on GBM and explored the target and mechanism of ASP through network pharmacology, molecular docking, and molecular biology experiments. We found that P53 is a potent target of ASP for GBM treatment, and its pharmacological mechanism is the activation of p53-dependent apoptosis. Our research provides an objective basis for the development and clinical application of ASP in GBM patients.