Advanced technologies for molecular diagnosis of cancer: State of pre-clinical tumor-derived exosome liquid biopsies

被引：39
作者：
Li, Lin [1 ,2 ,3 ,4 ]
Zhang, Lili [4 ,5 ]
Montgomery, Katelynn C. [6 ]
Jiang, Li [1 ,2 ,3 ]
Lyon, Christopher J. [4 ]
Hu, Tony Y. [4 ,6 ]
机构：
[1] Sichuan Acad Med Sci, Dept Lab Med, Chengdu, Peoples R China
[2] Sichuan Acad Med Sci, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu, Peoples R China
[3] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
[4] Tulane Univ, Sch Med, Ctr Cellular & Mol Diagnost, Dept Biochem & Mol Biol, New Orleans, LA 70118 USA
[5] HCA Florida Healthcare Westside Northwest Hosp In, Plantation, FL USA
[6] Tulane Univ, Sch Sci & Engn, Dept Biomed Engn, New Orleans, LA USA
来源：
MATERIALS TODAY BIO | 2023年 / 18卷
关键词：
Cancer; Molecular diagnosis; Exosome; Isolation; Enrichment; Laboratory developed tests; EXTRACELLULAR VESICLES; HEPATOCELLULAR-CARCINOMA; IN-VITRO; SERUM; CLASSIFICATION; BIOMARKERS; PROTEINS; URINE; CHIP;
D O I：
10.1016/j.mtbio.2022.100538
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Exosomes are membrane-defined extracellular vesicles (EVs) approximately 40-160 nm in diameter that are found in all body fluids including blood, urine, and saliva. They act as important vehicles for intercellular communication between both local and distant cells and can serve as circulating biomarkers for disease diagnosis and prognosis. Exosomes play a key role in tumor metastasis, are abundant in biofluids, and stabilize biomarkers they carry, and thus can improve cancer detection, treatment monitoring, and cancer staging/prognosis. Despite their clinical potential, lack of sensitive/specific biomarkers and sensitive isolation/enrichment and analytical technologies has posed a barrier to clinical translation of exosomes. This review presents a critical overview of technologies now being used to detect tumor-derived exosome (TDE) biomarkers in clinical specimens that have potential for clinical translation.
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页数：17
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