Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund's adjuvant-induced inflammatory pain

被引：18
作者：
Deng, Yi-Fan [1 ]
Xiang, Ping [2 ]
Du, Jing-Yi [1 ]
Liang, Jian-Fen [1 ]
Li, Xiang [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Dept Med Qual Management, Guangzhou, Guangdong, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 02期
关键词：
cell death; complete Freund's adjuvant; dorsal root ganglion; ferroptosis; inflammatory pain; intrathecal delivery liproxstatin-1; spinal cord; DORSAL-ROOT GANGLION; SPINAL-CORD; IRON; CATHETERIZATION; MODULATION; MODELS; TRPM2;
D O I：
10.4103/1673-5374.346547
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Previous studies have confirmed the relationship between iron-dependent ferroptosis and a peripheral nerve injury-induced neuropathic pain model. However, the role of ferroptosis in inflammatory pain remains inconclusive. Therefore, we aimed to explore whether ferroptosis in the spinal cord and dorsal root ganglion contributes to complete Freund's adjuvant (CFA)-induced painful behaviors in rats. Our results revealed that various biochemical and morphological changes were associated with ferroptosis in the spinal cord and dorsal root ganglion tissues of CFA rats. These changes included iron overload, enhanced lipid peroxidation, disorders of anti-acyl-coenzyme A synthetase long-chain family member 4 and glutathione peroxidase 4 levels, and abnormal morphological changes in mitochondria. Intrathecal treatment of liproxstatin-1 (a ferroptosis inhibitor) reversed these ferroptosis-related changes and alleviated mechanical and thermal hypersensitivities in CFA rats. Our study demonstrated the occurrence of ferroptosis in the spinal cord and dorsal root ganglion tissues in a rodent model of inflammatory pain and indicated that intrathecal administration of ferroptosis inhibitors, such as liproxstatin-1, is a potential therapeutic strategy for treating inflammatory pain.
引用
收藏
页码：456 / 462
页数：7
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