Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry

被引：5

作者：

Lacan, Claire ^{[1
]}

Lambert, Jerome ^{[2
,3
]}

Forcade, Edouard ^{[4
]}

Robin, Marie ^{[5
]}

Chevallier, Patrice ^{[6
]}

Loron, Sandrine ^{[7
]}

Bulabois, Claude-Eric ^{[8
]}

Orvain, Corentin ^{[9
]}

Ceballos, Patrice ^{[10
]}

Daguindau, Etienne ^{[11
]}

Charbonnier, Amandine ^{[12
]}

Chalandon, Yves ^{[13
]}

Bernard, Marc ^{[14
]}

Simand, Celestine ^{[15
]}

Rubio, Marie-Therese ^{[16
]}

Turlure, Pascal ^{[17
]}

Maertens, Johan ^{[18
]}

Huynh, Anne ^{[19
]}

Loschi, Michael ^{[20
]}

Bay, Jacques-Olivier ^{[21
]}

Guillerm, Gaelle ^{[22
]}

Alani, Mustafa ^{[23
]}

Castilla-Llorente, Cristina ^{[24
]}

Poire, Xavier ^{[25
]}

Chantepie, Sylvain ^{[26
]}

Maillard, Natacha ^{[27
]}

Beguin, Yves ^{[28
,29
]}

Marcais, Ambroise ^{[30
]}

Cornillon, Jerome ^{[31
]}

Malfuson, Jean-Valere ^{[32
]}

Maury, Sebastien ^{[33
]}

Meuleman, Nathalie ^{[34
]}

Villate, Alban ^{[35
]}

Bekadja, Mohammed-Amine ^{[36
]}

Walter-Petrich, Anouk ^{[2
,3
]}

Jacque, Nathalie ^{[1
]}

Srour, Micha ^{[37
]}

Devillier, Raynier ^{[38
]}

Nguyen, Stephanie ^{[1
]}

机构：

[1] Grp Hosp Pitie Salpetriere, AP HP, Clin Hematol Unit, 47-83 Bd Hop, F-75013 Paris, France

[2] INSERM, U1153, CRESS, Paris, France

[3] Hop St Louis, AP HP, Serv Biostat & Informat Med, Paris, France

[4] Ctr Hosp Univ Bordeaux, Clin Hematol Unit, Bordeaux, France

[5] Hop St Louis, AP HP, Clin Hematol Unit, Paris, France

[6] Ctr Hosp Univ Nantes, Clin Hematol Unit, Nantes, France

[7] HCL, Clin Hematol Unit, Hop Lyon Sud, Lyon, France

[8] Ctr Hosp Univ Grenoble, Clin Hematol Unit, Grenoble, France

[9] Ctr Hosp Univ Angers, Clin Hematol Unit, Angers, France

[10] Ctr Hosp Univ Montpellier, Clin Hematol Unit, Montpellier, France

[11] Ctr Hosp Univ Besancon, Clin Hematol Unit, Besancon, France

[12] Ctr Hosp Univ Amiens, Clin Hematol Unit, Amiens, France

[13] Hop Univ Geneve, Clin Hematol Unit, Geneva, Switzerland

[14] Ctr Hosp Univ Rennes, Clin Hematol Unit, Rennes, France

[15] Inst Cancerol Strasbourg Europe, Clin Hematol Unit, Strasbourg, France

[16] Ctr Hosp Univ Nancy, Clin Hematol Unit, Nancy, France

[17] Ctr Hosp Univ Dupuytren, Clin Hematol Unit, Limoges, France

[18] UZ Leuven, Dept Hematol, Leuven, Belgium

[19] IUCT Oncopole, Clin Hematol Unit, Toulouse, France

[20] Ctr Hosp Univ Nice, Clin Hematol Unit, Nice, France

[21] Ctr Hosp Univ Clermont Ferrand, Clin Hematol Unit, Clermont Ferrand, France

[22] Ctr Hosp Univ Brest, Clin Hematol Unit, Brest, France

[23] Ctr Henri Becquerel, Clin Hematol Unit, Rouen, France

[24] Inst Gustave Roussy, Clin Hematol Unit, Villejuif, France

[25] Clin Univ St Luc, Clin Hematol Unit, Leuven, Belgium

[26] Ctr Hosp Univ Caen, Clin Hematol Unit, Caen, France

[27] Ctr Hosp Univ Poitiers, Clin Hematol Unit, Poitiers, France

[28] Ctr Hosp Univ Liege, Clin Hematol Unit, Liege, Belgium

[29] Univ Liege, Liege, Belgium

[30] Hop Necker Enfants Malad, AP HP, Clin Hematol Unit, Paris, France

[31] Ctr Hosp Univ St Etienne, Clin Hematol Unit, St Etienne, France

[32] Hop Instruct Armees Percy, Clin Hematol Unit, Clamart, France

[33] Hop Henri Mondor, AP HP, Clin Hematol Unit, Creteil, France

[34] Inst Jules Bordet, Clin Hematol Unit, Brussels, Belgium

[35] Hop Bretonneau, Clin Hematol Unit, Tours, France

[36] EHU 1St November, Clin Hematol Unit, Clin Hematol & Cell Therapy, Oran, Algeria

[37] Ctr Hosp Univ Lille, Clin Hematol Unit, Lille, France

[38] Inst Paoli Calmette, Clin Hematol Unit, Marseille, France

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2024年 / 17卷 / 01期

关键词：

Haploidentical hematopoietic stem cell transplantation; Graft source; Bone marrow; Peripheral stem cell; Anti-thymoglobulin; DONOR TRANSPLANTATION; OUTCOMES;

D O I：

10.1186/s13045-023-01515-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis remains controversial. Moreover, the value of adding anti-thymoglobulin (ATG) to PTCy is unknown. A total of 1344 adult patients received an unmanipulated haploidentical transplant at 37 centers from 2012 to 2019 for hematologic malignancy. We compared the outcomes of patients according to the type of graft, using a propensity score analysis. In total population, grade II-IV and III-IV acute GVHD (aGVHD) were lower with BM than with PB. Grade III-IV aGVHD was lower with BM than with PB + ATG. All outcomes were similar in PB and PB + ATG groups. Then, in total population, adding ATG does not benefit the procedure. In acute leukemia, myelodysplastic syndrome and myeloproliferative syndrome (AL-MDS-MPS) subgroup receiving non-myeloablative conditioning, risk of relapse was twice greater with BM than with PB (51 vs. 22%, respectively). Conversely, risk of aGVHD was greater with PB (38% for aGVHD II-IV; 16% for aGVHD III-IV) than with BM (28% for aGVHD II-IV; 8% for aGVHD III-IV). In this subgroup with intensified conditioning regimen, risk of relapse became similar with PB and BM but risk of aGVHD III-IV remained higher with PB than with BM graft (HR = 2.0; range [1.17-3.43], p = 0.012).

引用

页数：5

共 12 条

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