HIV co-receptor tropism usage: first report from the Iranian patients

被引：2
|
作者：
Ghasabi, Farzaneh [1 ]
Hashempour, Ava [1 ]
Khodadad, Nastaran [1 ]
Akbarinia, Shokufeh [1 ]
Heydari, Mohammadreza [1 ]
Foroozanfar, Zohre [1 ]
机构：
[1] Shiraz Univ Med Sci, Inst Hlth, HIV AIDS Res Ctr, Shiraz, Iran
来源：
FUTURE VIROLOGY | 2023年 / 18卷 / 14期
关键词：
CCR5; coreceptor; CXCR4; HIV subtype; Iran; V3; tropism; CHEMOKINE RECEPTOR USE; GENOTYPIC ALGORITHMS; LARGE POPULATION; VIRAL TROPISM; SUBTYPE-D; MARAVIROC; RESISTANCE; CLASSIFICATION; EPIDEMIOLOGY; ASSOCIATION;
D O I：
10.2217/fvl-2023-0034
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: The HIV-V3 sequence influences tropism via the interaction of HIV with CCR5 and CXCR4 coreceptors; however, no consistent sequence accounts for R5 or X4-virus. Methods: RT-Nested PCR was performed to define V3-tropism in 123 samples using genotypic methods, including Geno2Pheno, WebPSSM, PhenoSeq, Net Charge and the 11/25 rule. Results: Among the samples studied, the HIV-1 R5 tropic viruses were predominant. However, X4 tropism could be a reason for the higher risk of treatment failure. A good accordance was observed between paired DNA/RNA tropism results. Conclusion: CCR5 inhibitors can be crucial in simplifying HIV treatment in Iranian patients. X4-virus is a risk factor for treatment failure. Proviral DNA (pvDNA) tropism result can be an appropriate target for V3-tropism determination.
引用
收藏
页码：955 / 969
页数：15
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