Influence of polymorphisms in CYP2C9, VKORC1, MDR1 and APOE genes on the warfarin maintenance dose in Brazilian patients

被引：2

作者：

Campos, Emilio Itamar de Freitas ^{[1
]}

Gomes, Karina Braga ^{[2
]}

Ribeiro, Daniel Dias ^{[3
]}

Puurunen, Marja Kaarina ^{[4
]}

Mourao, Aline deOliveira Magalhaes ^{[1
]}

Ferreira, Isadora Goncalves ^{[2
]}

Rocha, Manoel Otavio da Costa ^{[1
,3
]}

de Souza, Renan Pedra ^{[5
]}

Martins, Maria Auxiliadora Parreiras ^{[1
,2
,3
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Ave Prof Alfredo Balena 190, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Farm, Ave Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Hosp Clin, Ave Prof Alfredo Balena 110, BR-30130100 Belo Horizonte, MG, Brazil

[4] Boston Univ, 73 Mt Wayte Ave,Suite 2, Framingham, MA 01702 USA

[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Ave Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

来源：

PHARMACOGENOMICS | 2023年 / 24卷 / 13期

关键词：

APOE; genetic polymorphism; MDR1; VKORC1; warfarin; DOSING ALGORITHM; C3435T POLYMORPHISM; ORAL ANTICOAGULANT; REQUIREMENTS; DOSAGE; SUSCEPTIBILITY; SENSITIVITY; POPULATION; INTENSITY; GENOTYPE;

D O I：

10.2217/pgs-2023-0099

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Polymorphisms in the CYP2C9, VKORC1, MDR1 and APOE genes may impact warfarin dose. Aim: To investigate the influence of sociodemographic and clinical factors and polymorphisms *1, *2 and *3 for CYP2C9, -1639G > A for VKORC1, 3435C > T for MDR1, and epsilon 2, epsilon 3 and epsilon 4 for APOE genes on the mean weekly warfarin maintenance dose in adults. Methods: This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. Results: Themean age of patients was 64.1 +/- 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype VKORC1 GA, genotype VKORC1 AA, genotypes CYP2C9*1/*2 or *1/*3 and genotypes CYP2C9*2/*2 or *2/*3 or *3/*3 were associated with a reduced warfarin dose. Conclusion: This study pointed out factors that could impact the management of oral anticoagulation.

引用

页码：701 / 712

页数：12

共 38 条

[1] Oral Anticoagulant Therapy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Ageno, Walter ;

Gallus, Alexander S. ;

Wittkowsky, Ann ;

Crowther, Mark ;

Hylek, Elaine M. ;

Palareti, Gualtiero .

CHEST, 2012, 141 (02) :E44S-E88S

[2] Influence of PSRC1, CELSR2, and SORT1 Gene Polymorphisms on the Variability of Warfarin Dosage and Susceptibility to Cardiovascular Disease This [J].

AL-Eitan, Laith N. ;

Elsaqa, Barakat Z. ;

Almasri, Ayah Y. ;

Aman, Hatem A. ;

Khasawneh, Rame H. ;

Alghamdi, Mansour A. .

PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2020, 13 :619-632

[3] Influence of SH2B3, MTHFD1L, GGCX, and ITGB3 Gene Polymorphisms on theVariability on Warfarin Dosage Requirements and Susceptibility to CVD in the Jordanian Population [J].

AL-Eitan, Laith N. ;

Almasri, Ayah Y. ;

Khasawneh, Rame H. ;

Alghamdi, Mansour A. .

JOURNAL OF PERSONALIZED MEDICINE, 2020, 10 (03) :1-14

[4] Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy [J].

Al-Eitan, Laith N. ;

Almasri, Ayah Y. ;

Khasawneh, Rame H. .

SAUDI PHARMACEUTICAL JOURNAL, 2019, 27 (04) :484-490

[5] Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease [J].

Al-Eitan, Laith N. ;

Almasri, Ayah Y. ;

Al-Habahbeh, Sahar O. .

PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2019, 12 :15-22

[6] Effects of coagulation factor VII polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients during the initiation and maintenance phases of warfarin therapy [J].

Al-Eitan, Laith N. ;

Almasri, Ayah Y. ;

Al-Habahbeh, Sahar O. .

PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2019, 12 :1-8

[7] Impact of CYP2C9 and VKORC1 Polymorphisms on Warfarin Sensitivity and Responsiveness in Jordanian Cardiovascular Patients during the Initiation Therapy [J].

AL-Eitan, Laith N. ;

Almasri, Ayah Y. ;

Khasawneh, Rame H. .

GENES, 2018, 9 (12)

[8]

Al-Eitan Laith N., 2016, Current Pharmacogenomics & Personalized Medicine, V14, P7, DOI 10.2174/1875692115666161215103842

[9] Influence of genetic, biological and pharmacological factors on warfarin dose in a Southern Brazilian population of European ancestry [J].

Botton, Mariana Rodrigues ;

Bandinelli, Eliane ;

Paim Rohde, Luis Eduardo ;

Amon, Luis Carlos ;

Hutz, Mara Helena .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 72 (03) :442-450

[10] Genetic and Clinical Predictors of Warfarin Dose Requirements in African Americans [J].

Cavallari, L. H. ;

Langaee, T. Y. ;

Momary, K. M. ;

Shapiro, N. L. ;

Nutescu, E. A. ;

Coty, W. A. ;

Viana, M. A. G. ;

Patel, S. R. ;

Johnson, J. A. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (04) :459-464

← 1 2 3 4 →