Potential antihypertensive activity of novel peptides from green basil leaves

被引：2

作者：

Prangthip, Pattaneeya ^{[1
]}

Panbangred, Watanalai ^{[2
]}

Reamtong, Onrapak ^{[3
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok, Thailand

[2] King Mongkuts Univ Technol Thonburi, Res Innovat & Partnerships Off, Bangkok, Thailand

[3] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand

来源：

BMC COMPLEMENTARY MEDICINE AND THERAPIES | 2023年 / 23卷 / 01期

关键词：

Antihypertensive; Hypertension; Peptide; Ocimum tenuiflorum; Basil leaves; ACE-INHIBITORY PEPTIDES; ANTIOXIDANT PEPTIDES; BIOACTIVE PEPTIDES; HYPERTENSIVE-RATS; BLOOD-PRESSURE; IDENTIFICATION; PURIFICATION; BERBERINE; DISEASE; RISK;

D O I：

10.1186/s12906-023-04098-2

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Hypertension is among the risk factors of death globally. Novel antihypertensive peptides are alternative choices of antihypertensive assistance. This study aimed to discover novel antihypertensive peptides from green basil leaves. Two bioactive peptides with high angiotensin-converting enzyme inhibition (Asp-Leu-Ser-Ser-Ala-Pro; peptide 1) and antioxidant (Asp-Ser-Val-Ser-Ala-Ser-Pro; peptide 2) activities were gavaged to male Wistar rats induced with N-G-nitro-l-arginine methyl-ester (L-NAME). L-NAME-treated rats (HT) had decreased body weights and levels of nitrite and nitrate, which are metabolites of nitric oxide. The levels of their glucose and liver function indicators increased as compared to normal rats. HT rats receiving antihypertensive drugs (HTD) showed higher low-density lipoprotein and low-density lipoprotein/high-density lipoprotein levels than HT rats. Peptide 1 seems to benefit the rat lipid profiles, liver functions, antioxidant, nitrite, nitrate, and angiotensin II peptide levels but not peptide 2. In conclusion, our findings indicate the antihypertensive potential related to vasodilation of peptides from green basil leaves.

引用

页数：13

共 51 条

[21] Hypertensive Rats Treated Chronically With Nω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology [J].