BK DNAemia and native kidney polyomavirus nephropathy following lung transplantation

被引:6
作者
Dube, Geoffrey K. [1 ,4 ]
Batal, Ibrahim [2 ]
Shah, Lori [3 ]
Robbins, Hilary [3 ]
Arcasoy, Selim M. [3 ]
Husain, Syed Ali [1 ]
机构
[1] Columbia Univ, Irving Med Ctr, Dept Med, Div Nephrol, New York, NY USA
[2] Columbia Univ, Irving Med Ctr, Dept Pathol, New York, NY USA
[3] Columbia Univ, Irving Med Ctr, Dept Med, Div Pulm & Crit Care Med, New York, NY USA
[4] West 168th St, PH4-124, New York, NY 10032 USA
关键词
clinical research/practice; infectious disease; lung transplantation/pulmonology; kidney transplantation/nephrology infection; kidney (native) function/dysfunction; LONG-TERM OUTCOMES; VIRUS NEPHROPATHY; CYCLOSPORINE-A; REPLICATION; INFECTION; TACROLIMUS;
D O I
10.1016/j.ajt.2022.11.007
中图分类号
R61 [外科手术学];
学科分类号
摘要
BK virus DNAemia (BKPyV) and nephropathy are common after kidney transplant; however, there are limited data on BK infections in nonrenal solid organ transplant recipients. We examined the frequency, clinical and pathologic features, and kidney and lung outcomes of BKPyV and BK virus native kidney nephropathy (BKVN) in lung transplant recipients at our center. Among 878 recipients transplanted from 2003 to 2019, 56 (6%) devel-oped BKPyV at a median of 30.1 months after transplant (range, 0.6-213) and 11 (1.3%) developed BKVN at a median of 46 months after transplant (range, 9-213). The incidence of end-stage kidney disease was significantly higher in patients with peak viral load =10 000 copies/mL (39% vs 8%, P < .001). All cases of BKVN were in patients with peak viral load of =10 000 copies/mL, and 55% of these patients developed end-stage kidney disease. Despite the reduction of immunosuppression to treat BKVN, only 1 patient developed acute rejection, and lung function was stable >1 year. BKPyV and nephropathy are more common after lung transplantation than previously reported. Routine screening for BKPyV should be considered in all lung transplant recipients.
引用
收藏
页码:284 / 290
页数:7
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