Bibliometric analysis and review of research frontiers on Transient Receptor Potential Vanilloid 4 channels

The transient receptor potential vanilloid 4 (TRPV4) channel is a member of the TRP vanilloid sub-family in the TRP superfamily of ion channels. This study aimed to provide an overview of the research progression on TRPV4 channels, from initial discovery to present, using bibliometric meth-ods. TRPV4 channel-related articles published from 2000 onwards were retrieved from the Scopus database. Microsoft Excel and Harzing's Publish or Perish were used for the quantitative analysis of several characteristics of the retrieved articles. VOSviewer was used to construct networks based on the co-occurrence of author keywords. From 2000 onwards, 877 TRPV4 channel-related En-glish language articles written were published and included in the final bibliometric analysis. The number of publications appeared to fluctuate over the years; however, the number is predicted to increase over time. The Journal of Biological Chemistry ranked top for publishing 46 papers. Our co-occurrence analysis of author keywords revealed four main clusters: ``Cardiovascular-related,'' ``Channelopathies,'' ``Tumorigenesis,'' and ``Smooth muscle regulation.'' Our study also highlighted four main research frontiers of TRPV4: glaucoma, mitochondria, inflammation, and cell signaling. This is the first study to examine and demonstrate the trends and outlook for TRPV4 channel re-search using bibliometrics.