Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols

被引：9

作者：

Bera, Atanu ^{[1
]}

Ghosh, Adrija ^{[1
]}

Banerjee, Debasis ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttaranchal, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 11期

关键词：

BORROWING HYDROGEN;

D O I：

10.1021/acs.joc.3c00402

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we have demonstrated a simple nickel catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.

引用

页码：7162 / 7171

页数：10

共 41 条

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