The Relationship between Anxiety, Subjective and Objective Sleep, Chronotype and Circadian Rhythms with Depressive Symptoms in Insomnia Disorder

被引：9

作者：

Comas, Maria ^{[1
,2
,3
,4
]}

Solis Flores, Alejandra ^{[1
,10
]}

Lovato, Nicole ^{[5
]}

Miller, Christopher B. ^{[6
,7
]}

Bartlett, Delwyn J. ^{[1
,2
]}

Grunstein, Ronald R. ^{[1
,2
,8
,9
]}

Chapman, Julia ^{[1
]}

Gordon, Christopher J. ^{[1
,2
,8
]}

机构：

[1] Woolcock Inst Med Res, Ctr Sleep & Chronobiol, CIRUS, 431 Glebe Point Rd, Sydney, NSW 2037, Australia

[2] Univ Sydney, Fac Med & Hlth, Sci Rd, Camperdown, NSW 2050, Australia

[3] Univ Freiburg, Fac Med, Dept Med, Renal Div, D-79106 Freiburg, Germany

[4] Univ Freiburg, Med Ctr, D-79106 Freiburg, Germany

[5] Flinders Univ South Australia, Coll Med & Publ Hlth, Flinders Hlth & Med Res Inst Sleep Hlth, Formally Adelaide Inst Sleep Hlth,A Flinders Ctr, Sturt Rd, Adelaide, SA 5042, Australia

[6] Big Hlth Inc, 461 Bush St 200, San Francisco, CA 94108 USA

[7] Univ Oxford, John Radcliffe Hosp, Sleep & Circadian Neurosci Inst, Nuffield Dept Clin Neurosci, Level 6 West Wing, Oxford OX3 9DU, England

[8] CRC Alertness Safety & Prod, Melbourne, Vic 3800, Australia

[9] Royal Prince Alfred Hosp, Collaborat Ctr Cardiometab Hlth Psychoses, Charles Perkins Ctr, Johns Hopkins Dr Camperdown NSW 2006 Sydney Local, Sydney, NSW 2050, Australia

[10] Consultant Psychiatrist, 11 Coapa St Toriello Guerra Town Hall Tlalpan, Mexico City 14050, Mexico

来源：

BRAIN SCIENCES | 2023年 / 13卷 / 04期

关键词：

anxiety; chronotype; circadian preference; depressive symptoms; insomnia; melatonin; MELATONIN; EVENINGNESS; SEVERITY; VALIDITY; VERSION; ADULTS; INDEX; ONSET; RISK; TIME;

D O I：

10.3390/brainsci13040613

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Insomnia is a highly prevalent sleep disorder with strong bidirectional associations with depressive symptoms. The circadian preference for eveningness has been shown to be associated with depressive symptoms in insomnia and other mental health conditions. However, there is a lack of studies in insomnia investigating whether objective measures, such as dim light melatonin onset (DLMO) or polysomnographic (PSG) sleep, are associated with depressive symptoms. Therefore, we investigated the associations between subjective measures (questionnaires assessing anxiety, sleep quality and circadian preference, and sleep diary) and depressive symptoms and whether the addition of objective measures (DLMO, PSG parameters) would strengthen the associations with depressive symptoms. In 115 insomnia disorder patients we found that anxiety was strongly associated with depressive symptoms in a model including circadian preference, dysfunctional beliefs of sleep, and self-reported previous depressive symptoms (R-2 = 0.496, p < 0.001). The addition of sleep diary measures did not strengthen the model. We also found that the addition of objective measures (DLMO, PSG parameters) did not improve the subjective associations with depressive symptoms. Our data suggest that objective circadian markers are less important in the prediction of depressive symptoms in insomnia compared to subjective measures.

引用

页数：14

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