Epigenetic regulation of stem cells in lung cancer oncogenesis and therapy resistance

被引：11

作者：

Wu, Jiayang ^{[1
]}

Feng, Jiaming ^{[2
]}

Zhang, Qiran ^{[1
]}

He, Yazhou ^{[3
,4
,5
]}

Xu, Chuan ^{[5
]}

Wang, Chengdi ^{[1
]}

Li, Weimin ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Med X Ctr Mfg,Dept Pulm & Crit Care Med,Precis Med, Ctr Precis Med,West China Sch Med,Frontiers Sci Ct, Chengdu, Peoples R China

[2] Sichuan Univ, West China Sch Med, Chengdu, Peoples R China

[3] Sichuan Univ, West China Sch Publ Hlth, Dept Oncol, Chengdu, Peoples R China

[4] Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China

[5] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Dept Oncol, Chengdu, Peoples R China

来源：

FRONTIERS IN GENETICS | 2023年 / 14卷

关键词：

epigenetics; stem cells; lung cancer; tumor microenvironment; oncogenesis; therapy resistance; DNA METHYLATION; SOX2; ORIGIN; NOTCH; PROGRESSION; TARGETS; GENES; TRANSFORMATION; PROLIFERATION; CONTRIBUTES;

D O I：

10.3389/fgene.2023.1120815

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetics plays an important role in regulating stem cell signaling, as well as in the oncogenesis of lung cancer and therapeutic resistance. Determining how to employ these regulatory mechanisms to treat cancer is an intriguing medical challenge. Lung cancer is caused by signals that cause aberrant differentiation of stem cells or progenitor cells. The different pathological subtypes of lung cancer are determined by the cells of origin. Additionally, emerging studies have demonstrated that the occurrence of cancer treatment resistance is connected to the hijacking of normal stem cell capability by lung cancer stem cells, especially in the processes of drug transport, DNA damage repair, and niche protection. In this review, we summarize the principles of the epigenetic regulation of stem cell signaling in relation to the emergence of lung cancer and resistance to therapy. Furthermore, several investigations have shown that the tumor immune microenvironment in lung cancer affects these regulatory pathways. And ongoing experiments on epigenetics-related therapeutic strategies provide new insight for the treatment of lung cancer in the future.

引用

页数：11

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