Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles

被引:2
作者
Zhang, Qian [1 ]
Wang, Xiaolong [2 ]
Li, Zhishu [1 ]
Wang, Yinghua [1 ]
Lu, Hai'Ou [1 ]
Xiao, Yuhong [1 ]
Yu, Yuexin [1 ]
机构
[1] Gen Hosp Northern Theater Command, Dept Reprod Med, Shenyang, Peoples R China
[2] China Med Univ, Sch Forens Med, Dept Forens Pathol, Shenyang, Peoples R China
关键词
embryo transfer; pregnancy outcome; assisted reproductive technique; blood supply; frozen transfer cycles; EMBRYO-TRANSFER; IMPLANTATION; ULTRASONOGRAPHY; INFERTILITY; DOPPLER; FRESH;
D O I
10.3389/fphys.2023.1113853
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Background: The success of embryo transfer cycle depends mainly on the quality of embryo and endometrial receptivity. Ultrasound examination is still the most widely used non-invasive evaluation method for its advantages of convenience, non-invasiveness and repeatability. Ultrasound-measured endometrial blood flow is one of the important evaluation indicators of morphology. Aims: To investigate the effect of the number of endometrial blood flow branches on pregnancy outcome of frozen-thawed embryo transfer cycles which have undergoing hormone replacement therapy (HRT-FET). Material and methods: A retrospective cohort study was performed looking at a total of 1390 HRT-FET cycles from our reproductive medicine center between January 2017 to December 2021, which transferred one blastocyst frozen on day 5 with good quality in morphology. Associations between endometrial blood flow branches and pregnancy outcomes were evaluated with multivariable linear regression analysis. Results: The number of endometrial blood flow branches was independently associated with clinical pregnancy (OR 1.10; 95% CI 1.02-1.20). After adjusting for potential confounders, the effect size (odds ratio) was 1.09 (95% CI 1.00-1.19), and the results showed that the clinical pregnancy rate and live birth rate of T2 and T3 groups were significantly higher than those in group T1 (p < 0.05). Subgroup analysis showed that a consistent association between the endometrial blood flow branches and clinical pregnancy in all subgroups. Conclusion: Our study provided evidence for the influence of endometrial blood flow on pregnancy outcomes. There may be an independent association between the number of endometrial blood flow branches and pregnancy outcomes in frozen-thawed single blastocyst transfer cycles.
引用
收藏
页数:7
相关论文
共 33 条
[1]   Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles [J].
Aflatoonian, Abbas ;
Moghaddam, Fatemeh Mansoori ;
Mashayekhy, Mehri ;
Mohamadian, Farnaz .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2010, 27 (12) :695-700
[2]   RETRACTED: Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial (Retracted article. See vol. 30, pg. 1245, 2013) [J].
Aflatoonian, Abbas ;
Oskouian, Homa ;
Ahmadi, Shahnaz ;
Oskouian, Leila .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2010, 27 (07) :357-363
[3]   International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care [J].
Boivin, Jacky ;
Bunting, Laura ;
Collins, John A. ;
Nygren, Karl G. .
HUMAN REPRODUCTION, 2007, 22 (06) :1506-1512
[4]   Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis [J].
Craciunas, Laurentiu ;
Gallos, Ioannis ;
Chu, Justin ;
Bourne, Tom ;
Quenby, Siobhan ;
Brosens, Jan J. ;
Coomarasamy, Arri .
HUMAN REPRODUCTION UPDATE, 2019, 25 (02) :202-223
[5]  
DICKEY RP, 1993, FERTIL STERIL, V59, P756
[6]   International Committee for Monitoring Assisted Reproductive Technologies world report: Assisted Reproductive Technology 2008, 2009 and 2010 [J].
Dyer, S. ;
Chambers, G. M. ;
de Mouzon, J. ;
Nygren, K. G. ;
Zegers-Hochschild, F. ;
Mansour, R. ;
Ishihara, O. ;
Banker, M. ;
Adamson, G. D. .
HUMAN REPRODUCTION, 2016, 31 (07) :1588-1609
[7]   Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence [J].
Evans, Jemma ;
Hannan, Natalie J. ;
Edgell, Tracey A. ;
Vollenhoven, Beverley J. ;
Lutjen, Peter J. ;
Osianlis, Tiki ;
Salamonsen, Lois A. ;
Rombauts, Luk J. F. .
HUMAN REPRODUCTION UPDATE, 2014, 20 (06) :808-821
[8]   Angiogenesis occurs by vessel elongation in proliferative phase human endometrium [J].
Gambino, LS ;
Wreford, NG ;
Bertram, JF ;
Dockery, P ;
Lederman, F ;
Rogers, PAW .
HUMAN REPRODUCTION, 2002, 17 (05) :1199-1206
[9]   Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer [J].
Gardner, DK ;
Lane, M ;
Stevens, J ;
Schlenker, T ;
Schoolcraft, WB .
FERTILITY AND STERILITY, 2000, 73 (06) :1155-1158
[10]  
Gazdaru Smaranda, 2017, Rev Med Suisse, V13, P1832