Contribution of preoperative gut microbiota in postoperative neurocognitive dysfunction in elderly patients undergoing orthopedic surgery

被引：7

作者：

Bi, Jiangjiang ^{[1
,2
]}

Xu, Yifan ^{[1
,2
]}

Li, Shiyong ^{[1
,2
]}

Zhan, Gaofeng ^{[1
,2
]}

Hua, Dongyu ^{[1
,2
]}

Tan, Juan ^{[1
,2
]}

Chi, Xiaohui ^{[1
,2
]}

Xiang, Hongbing ^{[1
,2
]}

Guo, Fengjing ^{[3
]}

Luo, Ailin ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Anesthesiol, Hubei Key Lab Geriatr Anesthesia & Perioperat Brai, Tongji Hosp,Tongji Med Coll, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan Clin Res Ctr Geriatr Anesthesia, Wuhan, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Orthoped, Wuhan, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2023年 / 15卷

基金：

中国国家自然科学基金;

关键词：

gut microbiota; metabolites; orthopedic surgery; elderly patients; postoperative neurocognitive dysfunction; COGNITIVE DYSFUNCTION;

D O I：

10.3389/fnagi.2023.1108205

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To investigate the role of gut microbiota and metabolites in POCD in elderly orthopedic patients, and screen the preoperative diagnostic indicators of gut microbiota in elderly POCD.Method: 40 elderly patients undergoing orthopedic surgery were enrolled and divided into Control group and POCD group following neuropsychological assessments. Gut microbiota was determined by 16S rRNA MiSeq sequencing, and metabolomics of GC-MS and LC-MS was used to screen the differential metabolites. We then analyzed the pathways enriched by metabolites.Result: There was no difference in alpha or beta diversity between Control group and POCD group. There were significant differences in 39 ASV and 20 genera bacterium in the relative abundance. Significant diagnostic efficiency analyzed by the ROC curves were found in 6 genera bacterium. Differential metabolites in the two groups including acetic acid, arachidic acid, pyrophosphate etc. were screened out and enriched to certain metabolic pathways which impacted the cognition function profoundly.Conclusion: Gut microbiota disorders exist preoperatively in the elderly POCD patients, by which there could be a chance to predict the susceptible population.

引用

页数：12

共 21 条

[1] Helicobacter pylori moderates the association between 5-MTHF concentration and cognitive function in older adults [J].

Berrett, Andrew N. ;

Gale, Shawn D. ;

Erickson, Lance D. ;

Brown, Bruce L. ;

Hedges, Dawson W. .

PLOS ONE, 2018, 13 (01)

[2] Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 [J].

Bolyen, Evan ;

Rideout, Jai Ram ;

Dillon, Matthew R. ;

Bokulich, NicholasA. ;

Abnet, Christian C. ;

Al-Ghalith, Gabriel A. ;

Alexander, Harriet ;

Alm, Eric J. ;

Arumugam, Manimozhiyan ;

Asnicar, Francesco ;

Bai, Yang ;

Bisanz, Jordan E. ;

Bittinger, Kyle ;

Brejnrod, Asker ;

Brislawn, Colin J. ;

Brown, C. Titus ;

Callahan, Benjamin J. ;

Caraballo-Rodriguez, Andres Mauricio ;

Chase, John ;

Cope, Emily K. ;

Da Silva, Ricardo ;

Diener, Christian ;

Dorrestein, Pieter C. ;

Douglas, Gavin M. ;

Durall, Daniel M. ;

Duvallet, Claire ;

Edwardson, Christian F. ;

Ernst, Madeleine ;

Estaki, Mehrbod ;

Fouquier, Jennifer ;

Gauglitz, Julia M. ;

Gibbons, Sean M. ;

Gibson, Deanna L. ;

Gonzalez, Antonio ;

Gorlick, Kestrel ;

Guo, Jiarong ;

Hillmann, Benjamin ;

Holmes, Susan ;

Holste, Hannes ;

Huttenhower, Curtis ;

Huttley, Gavin A. ;

Janssen, Stefan ;

Jarmusch, Alan K. ;

Jiang, Lingjing ;

Kaehler, Benjamin D. ;

Bin Kang, Kyo ;

Keefe, Christopher R. ;

Keim, Paul ;

Kelley, Scott T. ;

Knights, Dan .

NATURE BIOTECHNOLOGY, 2019, 37 (08) :852-857

[3]

Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]

[4] Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults [J].

Cardenas, Victor M. ;

Boller, Francois ;

Roman, Gustavo C. .

BRAIN SCIENCES, 2019, 9 (12)

[5] Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation [J].

Chen, Chun ;

Liao, Jianming ;

Xia, Yiyuan ;

Liu, Xia ;

Jones, Rheinallt ;

Haran, John ;

McCormick, Beth ;

Sampson, Timothy Robert ;

Alam, Ashfaqul ;

Ye, Keqiang .

GUT, 2022, 71 (11) :2233-2252

[6] Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction [J].

Evered, Lisbeth ;

Silbert, Brendan ;

Scott, David A. ;

Ames, David ;

Maruff, Paul ;

Blennow, Kaj .

ANESTHESIOLOGY, 2016, 124 (02) :353-361

[7] Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease [J].

Fang, Evandro F. ;

Hou, Yujun ;

Palikaras, Konstantinos ;

Adriaanse, Bryan A. ;

Kerr, Jesse S. ;

Yang, Beimeng ;

Lautrup, Sofie ;

Hasan-Olive, Md Mahdi ;

Caponio, Domenica ;

Dan, Xiuli ;

Rocktaschel, Paula ;

Croteau, Deborah L. ;

Akbari, Mansour ;

Greig, Nigel H. ;

Fladby, Tormod ;

Nilsen, Hilde ;

Cader, M. Zameel ;

Mattson, Mark P. ;

Tavernarakis, Nektarios ;

Bohr, Vilhelm A. .

NATURE NEUROSCIENCE, 2019, 22 (03) :401-+

[8] Association between Helicobacter pylori infection and cognitive impairment in the elderly [J].

Han, Ming-Lun ;

Chen, Jen-Hau ;

Tsai, Min-Kuang ;

Liou, Jyh-Ming ;

Chiou, Jeng-Min ;

Chiu, Ming-Jang ;

Chen, Yen-Ching .

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2018, 117 (11) :994-1002

[9] Aging Differentially Affects the Loss of Neuronal Dendritic Spine, Neuroinflammation and Memory Impairment at Rats after Surgery [J].

Le, Yuan ;

Liu, Shuli ;

Peng, Mingchao ;

Tan, Chang ;

Liao, Qin ;

Duan, Kaiming ;

Ouyang, Wen ;

Tong, Jianbin .

PLOS ONE, 2014, 9 (09)

[10] Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort [J].

Liu, Ping ;

Wu, Li ;

Peng, Guoping ;

Han, Yuqiu ;

Tang, Ruiqi ;

Ge, Jianping ;

Zhang, Lijiang ;

Jia, Longfei ;

Yue, Siqing ;

Zhou, Kai ;

Li, Lanjuan ;

Luo, Benyan ;

Wang, Baohong .

BRAIN BEHAVIOR AND IMMUNITY, 2019, 80 :633-643

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