Synthesis and Insecticidal Activity of Novel Anthranilic Diamide Insecticides Containing Indane and Its Analogs

被引:0
|
作者
Yang, Zhihui [1 ]
Hu, Ruihan [1 ]
Chen, Jingjing [1 ]
Du, Xiaohua [1 ]
机构
[1] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, Zhejiang Green Pesticide Collaborat Innovat Ctr, Zhejiang Key Lab Green Pesticides & Cleaner Prod T, Hangzhou 310014, Peoples R China
关键词
diamide insecticides; indane; optically active; synthesis; insecticidal activity; RYANODINE RECEPTOR; PESTICIDE-RESIDUES; GOLDEN-AGE; POTENT; DOMAIN;
D O I
10.3390/ijms25042445
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diamide insecticides have always been a hot research topic in the field of pesticides. To further discover new compounds with high activity and safety, indane and its analogs were introduced into chlorantraniliprole, and a battery of chlorfenil derivatives, including indane and its analogs, were designed and prepared for biological testing. Their characterization and verification were carried out through nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Biological detection showed that all the compounds exhibited good insecticidal activity against Mythimna separata. At 0.8 mg/L, the insecticidal activity of compound 8q against Mythimna separata was 80%, which was slightly better than that of chlorantraniliprole. The results of the structure-activity relationship (SAR) analysis indicated that the indane moiety had a significant effect on insecticidal activity, especially in the R-configuration. The results indicated that chlorantraniliprole derivatives containing indane groups could serve as pilot compounds for the further development of new insecticides.
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页数:14
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