Increased risk of recurrence and disease-specific death following delayed postoperative radiation for Merkel cell carcinoma

被引：6

作者：

Alexander, Nora A. ^{[1
,2
]}

Schaub, Stephanie K. ^{[3
,4
,6
]}

Goff, Peter H. ^{[1
]}

Hippe, Daniel S. ^{[4
]}

Park, Song Y. ^{[1
]}

Lachance, Kristina ^{[1
]}

Bierma, Marika ^{[1
]}

Liao, Jay J. ^{[4
]}

Apisarnthanarax, Smith ^{[4
]}

Bhatia, Shailender ^{[3
,5
]}

Tseng, Yolanda D. ^{[3
,4
]}

Nghiem, Paul T. ^{[1
]}

Parvathaneni, Upendra ^{[3
,4
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA USA

[2] Washington Univ, Sch Med, Dept Med, Div Dermatol, St Louis, MO USA

[3] Univ Washington, Dept Radiat Oncol, Seattle, WA USA

[4] Fred Hutchinson Canc Ctr, Clin Res Div, Seattle, WA USA

[5] Univ Washington, Dept Med, Div Med Oncol, Seattle, WA USA

[6] Univ Washington, Sch Med, Dept Radiat Oncol, 1959 NE Pacific St Seattle, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2024年 / 90卷 / 02期

关键词：

adjuvant; carcinoma; dermatologic surgical procedures; Merkel Cell; patient outcome; THERAPY; HEAD; RADIOTHERAPY; IRRADIATION; SURGERY; PATIENT; TIME;

D O I：

10.1016/j.jaad.2023.07.1047

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Merkel cell carcinoma (MCC) is often treated with surgery and postoperative radiation therapy (PORT). The optimal time to initiate PORT (Time -to -PORT [ttPORT ]) is unknown. Purpose: We assessed if delays in ttPORT were associated with inferior outcomes. Methods: Competing risk regression was used to evaluate associations between ttPORT and locoregional recurrence (LRR) for patients with stage I/II MCC in a prospective registry and adjust for covariates. Distant metastasis and death were competing risks. Results: The cohort included 124 patients with median ttPORT of 41 days (range: 8-125 days). Median follow-up was 55 months. 17 (14%) patients experienced a LRR, 14 (82%) of which arose outside the radiation field. LRR at 5 years was increased for ttPORT [8 weeks vs # 8 weeks, 28.0% vs 9.2%, P = .006. There was an increase in the cumulative incidence of MCC-specific death with increasing ttPORT (HR = 1.14 per 1-week increase, P = .016). Limitations: The relatively low number of LRRs limited the extent of our multivariable analyses.

引用

页码：261 / 268

页数：8

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