Research progress on the mechanism of glycolysis in ovarian cancer

被引：12
作者：
Li, Chan [1 ]
Liu, Fang-Yuan [1 ]
Shen, Ying [1 ,2 ]
Tian, Yuan [3 ]
Han, Feng-Juan [2 ]
机构：
[1] Heilongjiang Univ Tradit Chinese Med TCM, Harbin, Heilongjiang, Peoples R China
[2] Heilongjiang Univ Tradit Chinese Med TCM, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
[3] Zhejiang Univ Chinese Med, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
ovarian cancer; glycolysis; hexokinase; phosphofructokinase; pyruvate kinase; CELL-PROLIFERATION; AEROBIC GLYCOLYSIS; METABOLISM; ACID; CHEMOTHERAPY; FIBROBLASTS; RESISTANCE; GROWTH; MYC;
D O I：
10.3389/fimmu.2023.1284853
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Glycolysis is the preferred energy metabolism pathway in cancer cells even when the oxygen content is sufficient. Through glycolysis, cancer cells convert glucose into pyruvic acid and then lactate to rapidly produce energy and promote cancer progression. Changes in glycolysis activity play a crucial role in the biosynthesis and energy requirements of cancer cells needed to maintain growth and metastasis. This review focuses on ovarian cancer and the significance of key rate-limiting enzymes (hexokinase, phosphofructokinase, and pyruvate kinase, related signaling pathways (PI3K-AKT, Wnt, MAPK, AMPK), transcription regulators (HIF-1a), and non-coding RNA in the glycolytic pathway. Understanding the relationship between glycolysis and these different mechanisms may provide new opportunities for the future treatment of ovarian cancer.
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收藏
页数：12
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