Marine-derived polysaccharides and their therapeutic potential in wound healing application - A review

被引:67
作者
Kumar, Mohit [1 ]
Kumar, Devesh [1 ]
Garg, Yogesh [1 ]
Mahmood, Syed [2 ]
Chopra, Shruti [3 ]
Bhatia, Amit [1 ,4 ]
机构
[1] Maharaja Ranjit Singh Punjab Tech Univ MRSPTU, Dept Pharmaceut Sci & Technol, Bathinda 151001, Punjab, India
[2] Univ Malaya, Fac Pharm, Dept Pharmaceut Technol, Kuala Lumpur 50603, Malaysia
[3] Amity Univ, Amity Inst Pharm, Noida 201313, Uttar Pradesh, India
[4] Maharaja Ranjit Singh Punjab Tech Univ MRSPTU, Dept Pharmaceut Sci & Technol, Bathinda 151001, Punjab, India
关键词
Marine polysaccharide; Chitosan; Alginate; Wound healing; Diabetic wound; CHITOSAN-BASED HYDROGEL; ACID-BASED HYDROGELS; IN-VITRO; GROWTH-FACTOR; SULFATED POLYSACCHARIDES; SODIUM ALGINATE; DRUG-DELIVERY; CROSS-LINKING; COMPOSITE SPONGES; TOXICOLOGICAL EVALUATION;
D O I
10.1016/j.ijbiomac.2023.127331
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polysaccharides originating from marine sources have been studied as potential material for use in wound dressings because of their desirable characteristics of biocompatibility, biodegradability, and low toxicity. Marine-derived polysaccharides used as wound dressing, provide several benefits such as promoting wound healing by providing a moist environment that facilitates cell migration and proliferation. They can also act as a barrier against external contaminants and provide a protective layer to prevent further damage to the wound. Research studies have shown that marine-derived polysaccharides can be used to develop different types of wound dressings such as hydrogels, films, and fibres. These dressings can be personalised to meet specific requirements based on the type and severity of the wound. For instance, hydrogels can be used for deep wounds to provide a moist environment, while films can be used for superficial wounds to provide a protective barrier. Additionally, these polysaccharides can be modified to improve their properties, such as enhancing their mechanical strength or increasing their ability to release bioactive molecules that can promote wound healing. Overall, marine-derived polysaccharides show great promise for developing effective and safe wound dressings for various wound types.
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页数:27
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