Role of lipins in cardiovascular diseases

被引：2
作者：
Ding, Zerui [1 ,2 ]
Song, Hongyu [1 ,2 ]
Wang, Fang [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Endocrinol Dept, Changsha 410013, Peoples R China
[2] Cent South Univ, Xiangya Sch Med, Changsha 410013, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2023年 / 22卷 / 01期
关键词：
Lipin; Cardiovascular diseases; Inflammation; Lipid metabolism; Triacylglycerol; ACTIVATED-RECEPTOR-GAMMA; PHOSPHATIDIC-ACID PHOSPHATASE; FATTY LIVER-DISEASE; CONGENITAL DYSERYTHROPOIETIC ANEMIA; RECURRENT MULTIFOCAL OSTEOMYELITIS; GENE-EXPRESSION; ADIPOSE-TISSUE; SUBCELLULAR-LOCALIZATION; TRIACYLGLYCEROL SYNTHESIS; INSULIN-RESISTANCE;
D O I：
10.1186/s12944-023-01961-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipin family members in mammals include lipins 1, 2, and 3. Lipin family proteins play a crucial role in lipid metabolism due to their bifunctionality as both transcriptional coregulators and phosphatidate phosphatase (PAP) enzymes. In this review, we discuss the structural features, expression patterns, and pathophysiologic functions of lipins, emphasizing their direct as well as indirect roles in cardiovascular diseases (CVDs). Elucidating the regulation of lipins facilitates a deeper understanding of the roles of lipins in the processes underlying CVDs. The activity of lipins is modulated at various levels, e.g., in the form of the transcription of genes, post-translational modifications, and subcellular protein localization. Because lipin characteristics are undergoing progressive clarification, further research is necessitated to then actuate the investigation of lipins as viable therapeutic targets in CVDs.
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页数：15
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