Weanling gut microbiota composition of a mouse model selectively bred for high voluntary wheel-running behavior

被引:0
作者
McNamara, Monica P. [1 ]
Venable, Emily M. [2 ]
Cadney, Marcell D. [3 ]
Castro, Alberto A. [1 ]
Schmill, Margaret P. [4 ,5 ]
Kazzazi, Lawrence [1 ]
Carmody, Rachel N. [2 ]
Garland, Theodore, Jr. [1 ]
机构
[1] Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 91521 USA
[2] Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA
[3] Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
[4] Univ Calif Riverside, Neurosci Grad Program, Riverside, CA 92521 USA
[5] Medpace, 717th St,Suite 500, Denver, CO 80202 USA
基金
美国国家科学基金会;
关键词
16S rRNA; Behavior; Exercise; Gut microbiota; Microbiome; Selection experiment; INTRINSIC AEROBIC CAPACITY; ARTIFICIAL SELECTION; BODY-COMPOSITION; INTESTINAL MICROBIOTA; GENETIC SELECTION; PHYSICAL-ACTIVITY; FOOD-CONSUMPTION; WESTERN DIET; MICE; EXERCISE;
D O I
10.1242/jeb.245081
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We compared the fecal microbial community composition and diversity of four replicate lines of mice selectively bred for high wheel-running activity over 81 generations (HR lines) and four non-selected control lines. We performed 16S rRNA gene sequencing on fecal samples taken 24 h after weaning, identifying a total of 2074 bacterial operational taxonomic units. HR and control mice did not significantly differ for measures of alpha diversity, but HR mice had a higher relative abundance of the family Clostridiaceae. These results differ from a study of rats, where a line bred for high forced-treadmill endurance and that also ran more on wheels had lower relative abundance of Clostridiaceae, as compared with a line bred for low endurance that ran less on wheels. Within the HR and control groups, replicate lines had unique microbiomes based on unweighted UniFrac beta diversity, indicating random genetic drift and/or multiple adaptive responses to selection.
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页数:7
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