Association between pre-diabetes or diabetes and cognitive impairment in a community-dwelling older population: Bushehr Elderly Health (BEH) program

被引：4

作者：

Farkhani, Sara ^{[1
]}

Payab, Moloud ^{[2
]}

Sharifi, Farshad ^{[3
]}

Sharifi, Yasaman ^{[1
,4
]}

Mohammadi, Sammy ^{[1
]}

Shadman, Zhaleh ^{[3
]}

Fahimfar, Noushin ^{[5
]}

Heshmat, Ramin ^{[6
]}

Hadizadeh, Alireza ^{[7
]}

Shafiee, Gita ^{[6
]}

Nabipour, Iraj ^{[8
]}

Tavakoli, Farnaz ^{[9
]}

Larijani, Bagher ^{[1
]}

Ebrahimpur, Mahbube ^{[1
,3
]}

Ostovar, Afshin ^{[5
]}

机构：

[1] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran

[2] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran

[3] Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Radiol, Tehran, Iran

[5] Univ Tehran Med Sci, Osteoporosis Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran

[6] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran

[7] Univ Tehran Med Sci, Cardiovasc Dis Res Inst, Res Ctr Adv Technol Cardiovasc Med, Tehran, Iran

[8] Bushehr Univ Med Sci, Persian Gulf Biomed Sci Res Inst, Persian Gulf Marine Biotechnol Res Ctr, Bushehr, Iran

[9] Univ Tehran Med Sci, Shariati Hosp, Nephrol & Kidney Transplant Ward, Tehran, Iran

来源：

JOURNAL OF DIABETES AND METABOLIC DISORDERS | 2024年 / 23卷 / 01期

关键词：

Pre-diabetes; Diabetes; Cognitive impairment; Aged; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; BRAIN ATROPHY; MELLITUS; PREVALENCE; DEMENTIA; RISK; METAANALYSIS; DYSFUNCTION; PEOPLE;

D O I：

10.1007/s40200-023-01325-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundPersistent uncontrolled hyperglycemia is recognized as one of the risk factors for cognitive disorders. Accordingly, both type 1 and type 2 diabetes may predispose individuals to cognitive impairment, particularly in cases where glycemic control is insufficient. The objective of this comprehensive study is to separately assess cognitive dysfunctions in diabetic and non-diabetic older adults.MethodsThis cross-sectional study is part of phase 2 of the Bushehr elderly health program (BEHP). Cognitive function was evaluated using the Mini-cog and categorical verbal fluency tests (CFTs). Patients were classified as non-diabetics, pre-diabetics, or diabetics based on the diagnostic criteria for diabetes mellitus (DM). To compare the means of the two groups, we utilized the t-test or the Mann-Whitney test. Additionally Multivariable logistic regression models were used to determine the association between pre-diabetes or DM and cognitive impairment.ResultsOut of 1533 participants, 693 (45.2%) were identified as having cognitive impairment. The average hemoglobin A1C was higher in participants with cognitive impairment compared to those without cognitive impairment. (5.8 +/- 1.6% vs. 5.5 +/- 1.4%, P = 0.004). Furthermore, the mean blood glucose levels were found to be more elevated in cases of cognitive impairment (108.0 +/- 47.4 mg/dL vs. 102.1 +/- 0.35 mg/dL, P = 0.002). After adjusting for age, gender, body mass index (BMI), waist circumference, amount of physical activity, and smoking, the multivariable logistic regression model, declared an association between diabetes and cognitive impairment (OR = 1.48, P = 0.003). In addition, older patients, females, widows, and individuals with elevated LDL-Cs and those with high blood pressure were found to be more vulnerable to cognitive impairment.ConclusionThe Bushehr Elderly Health Program (BEHP) study revealed that individuals affected with cognitive impairment may exhibit higher levels of HbA1c. This suggests a positive correlation between elevated HbA1c and cognitive impairment.

引用

页码：639 / 646

页数：8

共 44 条

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