Visible-light-induced alkoxycarbonylation/cyclization of 1,7-enynes: synthesis of dihydropyranones containing all-carbon quaternary centers

被引：16
|
作者：
Chen, Jian-Qiang [1 ,2 ]
Chen, Qi [1 ,2 ]
Chen, Baofu [1 ,2 ]
Wu, Jie [1 ,2 ,3 ,4 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China
[2] Taizhou Univ, Taizhou Univ Hosp, Taizhou Cent Hosp, Taizhou 318000, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 08期
基金：
中国国家自然科学基金;
关键词：
CATALYZED ENANTIOSELECTIVE ANNULATION; PHOTOREDOX CATALYSIS; ASYMMETRIC-SYNTHESIS; CYCLIZATION; ACTIVATION; ALDEHYDES; ACCESS; ACID;
D O I：
10.1039/d3qo00213f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct photoredox catalyzed radical-triggered tandem cyclization of 1,7-enynes with alkyloxalyl chlorides is developed. With this approach, a variety of dihydropyranones containing all-carbon quaternary centers are prepared through alkoxycarbonylation/6-exo-dig cyclization/6-endo-trig cyclization with 1,7-enynes under mild conditions. More importantly, this approach provides a new route to polysubstituted dihydropyranones.
引用
收藏
页码：2018 / 2023
页数：6
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