Time-dependent changes in RPILD and mortality risk in anti-MDA5+DM patients: a cohort study of 272 cases in China

被引：35

作者：

You, Hanxiao ^{[1
]}

Wang, Lei ^{[1
]}

Wang, Jiajia ^{[1
]}

Lv, Chengyin ^{[1
]}

Xu, Lingxiao ^{[1
]}

Yuan, Fenghong ^{[2
]}

Li, Ju ^{[3
]}

Wu, Min ^{[4
]}

Zhou, Shiliang ^{[4
]}

Da, Zhanyun ^{[5
]}

Qian, Jie ^{[5
]}

Wei, Hua ^{[6
]}

Yan, Wei ^{[6
]}

Zhou, Lei ^{[7
]}

Wang, Yan ^{[7
]}

Yin, Songlou ^{[8
]}

Zhou, Dongmei ^{[8
]}

Wu, Jian ^{[9
]}

Lu, Yan ^{[10
]}

Su, Dinglei ^{[11
]}

Liu, Zhichun ^{[12
]}

Liu, Lin ^{[13
]}

Ma, Longxin ^{[14
]}

Xu, Xiaoyan ^{[15
]}

Zang, Yinshan ^{[16
]}

Liu, Huijie ^{[17
]}

Ren, Tianli ^{[18
]}

Wang, Fang ^{[19
]}

Zhang, Miaojia ^{[1
]}

Tan, Wenfeng ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Rheumatol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Rheumatol & Immunol, Affiliated Wuxi Peoples Hosp, Wuxi, Jiangsu, Peoples R China

[3] Huaian First Peoples Hosp, Dept Rheumatol, Huaian, Jiangsu, Peoples R China

[4] First Peoples Hosp Changzhou, Dept Rheumatol, Changzhou, Jiangsu, Peoples R China

[5] Nantong Univ, Dept Rheumatol, Affiliated Hosp, Nantong, Jiangsu, Peoples R China

[6] Northern Jiangsu Peoples Hosp, Dept Rheumatol, Yangzhou, Jiangsu, Peoples R China

[7] Changzhou 2 Peoples Hosp, Dept Rheumatol, Changzhou, Jiangsu, Peoples R China

[8] Xuzhou Med Univ, Dept Rheumatol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China

[9] Soochow Univ, Dept Rheumatol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China

[10] Jiangsu Prov Hosp Chinese Med, Dept Rheumatol, Nanjing, Jiangsu, Peoples R China

[11] Nanjing First Hosp, Dept Rheumatol, Nanjing, Jiangsu, Peoples R China

[12] Soochow Univ, Dept Rheumatol, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China

[13] Xuzhou Cent Hosp, Dept Rheumatol, Xuzhou, Jiangsu, Peoples R China

[14] Yancheng 1 Peoples Hosp, Dept Rheumatol, Yancheng, Jiangsu, Peoples R China

[15] Southeast Univ, Dept Rheumatol, Zhongda Hosp, Nanjing, Jiangsu, Peoples R China

[16] Nanjing Med Univ, Dept Rheumatol, Affiliated Suqian Peoples Hosp 1, Suqian, Jiangsu, Peoples R China

[17] First Peoples Hosp Lianyungang, Dept Rheumatol, Lianyungang, Jiangsu, Peoples R China

[18] Wuxi 2 Peoples Hosp, Dept Rheumatol, Wuxi, Jiangsu, Peoples R China

[19] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China

来源：

RHEUMATOLOGY | 2023年 / 62卷 / 03期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

DM; MDA5; interstitial lung disease; RPILD; time-dependent; INTERSTITIAL LUNG-DISEASE; AMYOPATHIC DERMATOMYOSITIS; CLINICAL SPECTRUM; JAPANESE PATIENTS; RIG-I; POLYMYOSITIS; UTILITY; MDA5;

D O I：

10.1093/rheumatology/keac450

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives Anti-melanoma differentiation-associated gene 5 positive (anti-MDA5+) DM has a close relationship with rapidly progressive interstitial lung disease (RPILD) and is associated with high mortality. However, data regarding the time-dependent risk of RPILD and deaths during disease progression are limited. We conducted this study to investigate whether the risk of RPILD and death were time-dependent or not in anti-MDA5+ DM. Methods We assessed a cohort of 272 patients with anti-MDA5+ DM. The clinical characteristics of patients with anti-MDA5+ were collected, and COX regression was used to analyse independent risk factors for RPILD and death. We also described changes in risk of RPILD and death over time and their potential clinical implications. Results There were 272 anti-MDA5+ DM patients enrolled in this study. According to the multivariate cox regression analysis, short disease course, high CRP level, anti-Ro52 positive and anti-MDA5 titre (++similar to+++) were independent risk factors of RPILD. High creatine kinase level, high CRP level and RPILD were independent risk factors for death, and >90% RPILD and 84% mortality occurred in the first 6 months after disease onset. Notably, the first 3 months is a particularly high-risk period, with 50% of RPILD and 46% of deaths occurring. Hazards regarding RPILD and mortality diminished over time during a median follow-up of 12 months. Conclusion These results suggest significant, time-dependent changes in RPILD and mortality risk in anti-MDA5+ DM patients, providing a cut-off time window to estimate disease progression and poor prognosis.

引用

页码：1216 / 1226

页数：11

共 34 条

[21] Seasonal and residential clustering at disease onset of anti-MDA5-associated interstitial lung disease [J].

Nishina, Naoshi ;

Sato, Shinji ;

Masui, Kenichi ;

Gono, Takahisa ;

Kuwana, Masataka .

RMD OPEN, 2020, 6 (02)

[22] SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells [J].

Rebendenne, Antoine ;

Valadao, Ana Luiza Chaves ;

Tauziet, Marine ;

Maarifi, Ghizlane ;

Bonaventure, Boris ;

McKellar, Joe ;

Planes, Remi ;

Nisole, Sebastien ;

Arnaud-Arnould, Mary ;

Moncorge, Olivier ;

Goujon, Caroline .

JOURNAL OF VIROLOGY, 2021, 95 (08)

[23]

Rebora P, 2014, R J, V6, P114

[24] The RNA sensor MDA5 detects SARS-CoV-2 infection [J].

Sampaio, Natalia G. ;

Chauveau, Lise ;

Hertzog, Jonny ;

Bridgeman, Anne ;

Fowler, Gerissa ;

Moonen, Jurgen P. ;

Dupont, Maeva ;

Russell, Rebecca A. ;

Noerenberg, Marko ;

Rehwinkel, Jan .

SCIENTIFIC REPORTS, 2021, 11 (01)

[25] Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis [J].

Sato, S ;

Hirakata, M ;

Kuwana, M ;

Suwa, A ;

Inada, S ;

Mimori, T ;

Nishikawa, T ;

Oddis, CV ;

Ikeda, Y .

ARTHRITIS AND RHEUMATISM, 2005, 52 (05) :1571-1576

[26] Pharmacologic Treatment of Anti-MDA5 Rapidly Progressive Interstitial Lung Disease [J].

Selva-O'Callaghan, A. ;

Romero-Bueno, F. ;

Trallero-Araguas, E. ;

Gil-Vila, A. ;

Ruiz-Rodriguez, J. C. ;

Sanchez-Pernaute, O. ;

Pinal-Fernandez, I. .

CURRENT TREATMENT OPTIONS IN RHEUMATOLOGY, 2021, 7 (04) :319-333

[27] Virus-specific editing identification approach reveals the landscape of A-to-I editing and its impacts on SARS-CoV-2 characteristics and evolution [J].

Song, Yulong ;

He, Xiuju ;

Yang, Wenbing ;

Wu, Yaoxing ;

Cui, Jun ;

Tang, Tian ;

Zhang, Rui .

NUCLEIC ACIDS RESEARCH, 2022, 50 (05) :2509-2521

[28] Infections and respiratory tract disease as risk factors for idiopathic inflammatory myopathies: a population-based case-control study [J].

Svensson, John ;

Holmqvist, Marie ;

Lundberg, Ingrid E. ;

Arkema, Elizabeth V. .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (11) :1803-1808

[29]

Therneau TM, 2000, Modeling Survival Data: Extending the Cox Model. Statistics for Biology and Health, DOI [10.1007/978-1-4757-3294-8_6, DOI 10.1007/978-1-4757-3294-8_6]

[30] Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis [J].

Tsuji, Hideaki ;

Nakashima, Ran ;

Hosono, Yuji ;

Imura, Yoshitaka ;

Yagita, Masato ;

Yoshifuji, Hajime ;

Hirata, Shintaro ;

Nojima, Takaki ;

Sugiyama, Eiji ;

Hatta, Kazuhiro ;

Taguchi, Yoshio ;

Katayama, Masaki ;

Tanizawa, Kiminobu ;

Handa, Tomohiro ;

Uozumi, Ryuji ;

Akizuki, Shuji ;

Murakami, Kosaku ;

Hashimoto, Motomu ;

Tanaka, Masao ;

Ohmura, Koichiro ;

Mimori, Tsuneyo .

ARTHRITIS & RHEUMATOLOGY, 2020, 72 (03) :488-498

← 1 2 3 4 →