NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

被引：2

作者：

Doelling, Maximilian ^{[1
]}

Herrmann, Martin ^{[2
,3
,4
]}

Boettcher, Michael ^{[4
]}

机构：

[1] Univ Hosp Magdeburg, Dept Gen Visceral Vasc & Transplant Surg, D-39120 Magdeburg, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med 3, Rheumatol & Immunol, Univ Klinikum Erlangen, D-91054 Erlangen, Germany

[3] Friedrich Alexander Univ Erlangen Nurnberg, Deutsch Zentrum Immuntherapie DZI, Univ Klinikum Erlangen FAU, D-91054 Erlangen, Germany

[4] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Pediat Surg, D-68167 Mannheim, Germany

来源：

CHILDREN-BASEL | 2024年 / 11卷 / 03期

关键词：

extracellular traps; thromboinflammation; diabetes mellitus; tissue adhesions; wound healing; appendicitis; necrotizing enterocolitis; burns; gallstones; tumor microenvironment; NECROTIZING ENTEROCOLITIS; VENOUS THROMBOSIS; ABDOMINAL-SURGERY; APPENDICITIS; INJURY; PATHOGENESIS; ADHESIONS; IMMUNITY; SEPSIS; MICE;

D O I：

10.3390/children11030295

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in pediatric surgery. Focusing on NET formation, functions, and implications, this study highlights their dual impact in infection control and contribution to tissue damage after surgery. It covers the role of NET formation in a range of pediatric conditions including immunothrombosis, formation of peritoneal adhesions, appendicitis, burns, gallstones, tumors, and necrotizing enterocolitis (NEC). The results underscore the significance of NETs in fighting infections and their association with complications like sepsis and delayed wound healing. The breakdown products of NETs as a diagnostic tool of the clinical course of acute appendicitis will also be discussed. Understanding NET formation in the pathophysiology can potentially help to find new therapeutic approaches such as the application of DNase and elastase inhibitors to change the clinical course of various diseases in pediatric surgery such as improvement of wound healing, adhesion formation, NEC, and many more.

引用

页数：15

共 139 条

[1] THE EPIDEMIOLOGY OF APPENDICITIS AND APPENDECTOMY IN THE UNITED-STATES [J].

ADDISS, DG ;

SHAFFER, N ;

FOWLER, BS ;

TAUXE, RV .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (05) :910-925

[2] PHYSICOCHEMICAL BASIS OF CHOLESTEROL GALLSTONE FORMATION IN MAN [J].

ADMIRAND, WH ;

SMALL, DM .

JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (05) :1043-&

[3] Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 [J].

Adrover, Jose M. ;

Carrau, Lucia ;

Dassler-Plenker, Juliane ;

Bram, Yaron ;

Chandar, Vasuretha ;

Houghton, Sean ;

Redmond, David ;

Merrill, Joseph R. ;

Shevik, Margaret ;

TenOever, Benjamin R. ;

Lyons, Scott K. ;

Schwartz, Robert E. ;

Egeblad, Mikala .

JCI INSIGHT, 2022, 7 (05)

[4] Neutrophils in Homeostasis, Immunity, and Cancer [J].

Angel Nicolas-Avila, Jose ;

Adrover, Jose M. ;

Hidalgo, Andres .

IMMUNITY, 2017, 46 (01) :15-28

[5] A Selective Phosphodiesterase-4 Inhibitor Reduces Leukocyte Infiltration, Oxidative Processes, and Tissue Damage after Spinal Cord Injury [J].

Bao, Feng ;

Fleming, Jennifer C. ;

Golshani, Roozbeh ;

Pearse, Damien D. ;

Kasabov, Levent ;

Brown, Arthur ;

Weaver, Lynne C. .

JOURNAL OF NEUROTRAUMA, 2011, 28 (06) :1035-1049

[6] Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis [J].

Belaaouaj, A .

MICROBES AND INFECTION, 2002, 4 (12) :1259-1264

[7] A proposed role for neutrophil extracellular traps in cancer immunoediting [J].

Berger-Achituv, Sivan ;

Brinkmann, Volker ;

Abu Abed, Ulrike ;

Kuehn, Lars I. ;

Ben-Ezra, Jonathan ;

Elhasid, Ronit ;

Zychlinsky, Arturo .

FRONTIERS IN IMMUNOLOGY, 2013, 4

[8]

Boettcher Michael, 2022, Surgery, V171, P312, DOI 10.1016/j.surg.2021.07.010

[9] Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study [J].

Boettcher, Michael ;

Esser, Melina ;

Trah, Julian ;

Klohs, Stefan ;

Mokhaberi, Nariman ;

Wenskus, Julia ;

Trochimiuk, Madgalena ;

Appl, Birgit ;

Reinshagen, Konrad ;

Raluy, Laia Pagerols ;

Klinke, Michaela .

SCIENTIFIC REPORTS, 2020, 10 (01)

[10] Risk Factors, Complications, and Outcomes of Gallstones in Children: A Single-center Review [J].

Bogue, Conor O. ;

Murphy, Amanda J. ;

Gerstle, J. Ted ;

Moineddin, Rahim ;

Daneman, Alan .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (03) :303-308

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