Validation of biomarkers of aging

被引：61

作者：

Moqri, Mahdi ^{[1
,2
,3
]}

Herzog, Chiara ^{[4
]}

Poganik, Jesse R. ^{[1
]}

Ying, Kejun ^{[1
,5
]}

Justice, Jamie N. ^{[6
]}

Belsky, Daniel W. ^{[7
]}

Higgins-Chen, Albert T. ^{[8
]}

Chen, Brian H. ^{[9
]}

Cohen, Alan A. ^{[10
]}

Fuellen, Georg ^{[11
,12
]}

Haegg, Sara ^{[13
]}

Marioni, Riccardo E. ^{[14
]}

Widschwendter, Martin ^{[4
,15
,16
]}

Fortney, Kristen ^{[17
]}

Fedichev, Peter O. ^{[18
]}

Zhavoronkov, Alex ^{[19
]}

Barzilai, Nir ^{[20
]}

Lasky-Su, Jessica ^{[21
]}

Kiel, Douglas P. ^{[22
,23
,24
]}

Kennedy, Brian K. ^{[25
,26
]}

Cummings, Steven ^{[27
,28
]}

Slagboom, P. Eline ^{[29
]}

Verdin, Eric ^{[30
]}

Maier, Andrea B. ^{[26
,31
]}

Sebastiano, Vittorio ^{[3
]}

Snyder, Michael P. ^{[2
]}

Gladyshev, Vadim N. ^{[1
]}

Horvath, Steve ^{[32
]}

Ferrucci, Luigi ^{[33
]}

机构：

[1] Brigham & Womens Hosp, Harvard Med Sch, Dept Med, Div Genet, Boston, MA 02115 USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA

[3] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA USA

[4] Univ Innsbruck, European Translat Oncol Prevent & Screening Inst, Innsbruck, Austria

[5] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA USA

[6] Wake Forest Univ, Sch Med, Dept Internal Med, Sect Gerontol & Geriatr Med, Winston Salem, NC USA

[7] Columbia Univ, Butler Columbia Aging Ctr, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[8] Yale Univ, Dept Psychiat, New Haven, CT USA

[9] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA USA

[10] Columbia Univ, Mailman Sch Publ Hlth, Butler Columbia Aging Ctr, Dept Environm Hlth Sci, New York, NY USA

[11] Rostock Univ, Med Ctr, Inst Biostat & Informat Med & Ageing Res, Rostock, Germany

[12] Univ Coll Dublin, Sch Med, Dublin, Ireland

[13] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[14] Univ Edinburgh, Inst Genet & Canc, Ctr Genom & Expt Med, Edinburgh, Scotland

[15] UCL, EGA Inst Womens Hlth, Dept Womens Canc, London, England

[16] Karolinska Inst, Div Obstet & Gynaecol, Dept Womens & Childrens Hlth, Stockholm, Sweden

[17] Bioage Labs, Richmond, CA USA

[18] Gero PTE, Singapore, Singapore

[19] Insilico Med Hong Kong, Hong Kong, Peoples R China

[20] Inst Aging Res, Albert Einstein Coll Med, Bronx, NY USA

[21] Harvard Med Sch, Brigham & Womens Hosp, Dept Network Med, Boston, MA USA

[22] Hinda & Arthur Marcus Inst Aging Res, Musculoskeletal Res Ctr, Boston, MA USA

[23] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA

[24] Harvard Med Sch, Boston, MA USA

[25] Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore

[26] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Hlth Longev Translat Res Program, AgeSingapore,Ctr Hlth Longev,Natl Univ Singapore, Singapore, Singapore

[27] Calif Pacific Med Ctr Res Inst, San Francisco Coordinating Ctr, San Francisco, CA USA

[28] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[29] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Sect Mol Epidemiol, Leiden, Netherlands

[30] Buck Inst Res Aging, Novato, CA USA

[31] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Amsterdam Movement Sci, Dept Human Movement Sci,AgeAmsterdam, Amsterdam, Netherlands

[32] Altos Labs, San Diego, CA 92121 USA

[33] Natl Inst Aging, Baltimore, MD 21224 USA

来源：

NATURE MEDICINE | 2024年 / 30卷 / 02期

关键词：

EPIGENETIC CLOCKS; DNA METHYLATION; LIFE-SPAN; AGE; PROFILES; BIOBANK; DESIGN; HEALTH; FUTURE;

D O I：

10.1038/s41591-023-02784-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The search for biomarkers that quantify biological aging (particularly 'omic'-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. Here, we review current efforts to evaluate the predictive validity of omic biomarkers of aging in population studies, discuss challenges in comparability and generalizability and provide recommendations to facilitate future validation of biomarkers of aging. Finally, we discuss how systematic validation can accelerate clinical translation of biomarkers of aging and their use in gerotherapeutic clinical trials. Robust validation of biomarkers of aging will be critical to their clinical translation; here, authors review the key challenges and propose recommendations to overcome them.

引用

页码：360 / 372

页数：13

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