Flavonoids, gut microbiota, and host lipid metabolism

被引：20

作者：

Zhou, Miao ^{[1
]}

Ma, Jie ^{[1
]}

Kang, Meng ^{[1
]}

Tang, Wenjie ^{[2
,3
]}

Xia, Siting ^{[1
,4
]}

Yin, Jie ^{[1
]}

Yin, Yulong ^{[1
]}

机构：

[1] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China

[2] Sichuan Animtech Feed Co Ltd, Livestock & Poultry Biol Prod Key Lab Sichuan Prov, Sichuan Anim Sci Acad, Chengdu, Sichuan, Peoples R China

[3] Sichuan Animtech Feed Co Ltd, Livestock & Poultry Biol Prod Key Lab Sichuan Prov, Sichuan Anim Sci Acad, Chengdu 610066, Sichuan, Peoples R China

[4] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China

来源：

ENGINEERING IN LIFE SCIENCES | 2024年 / 24卷 / 05期

关键词：

flavonoids; gut microbiota; lipid metabolism; metabolites; polyphenol; HIGH-FAT-DIET; ENHANCES GLUCOSE-UPTAKE; ONION PEEL EXTRACT; SHORT-CHAIN; INTESTINAL MICROBIOTA; OXIDATIVE STRESS; GENE-EXPRESSION; PPAR-GAMMA; ANTIBACTERIAL ACTIVITY; INSULIN-RESISTANCE;

D O I：

10.1002/elsc.202300065

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Flavonoids are widely distributed in nature and have a variety of beneficial biological effects, including antioxidant, anti-inflammatory, and anti-obesity effects. All of these are related to gut microbiota, and flavonoids also serve as a bridge between the host and gut microbiota. Flavonoids are commonly used to modify the composition of the gut microbiota by promoting or inhibiting specific microbial species within the gut, as well as modifying their metabolites. In turn, the gut microbiota extensively metabolizes flavonoids. Hence, this reciprocal relationship between flavonoids and the gut microbiota may play a crucial role in maintaining the balance and functionality of the metabolism system. In this review, we mainly highlighted the biological effects of antioxidant, anti-inflammatory and antiobesity, and discussed the interaction between flavonoids, gut microbiota and lipid metabolism, and elaborated the potential mechanisms on host lipid metabolism.

引用

页数：19

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