Role of Non-coding RNA in the Pathogenesis of Intestinal Ischemia- Reperfusion Injury

被引：4

作者：

Zhang, Jianmin ^{[1
]}

Liu, Zhenzhen ^{[1
]}

Liu, Yongqiang ^{[1
,2
]}

Shi, Yajing ^{[1
]}

Chen, Feng ^{[1
]}

Leng, Yufang ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Dept Anesthesiol, Hosp 1, Lanzhou 730000, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2023年 / 30卷 / 36期

基金：

中国国家自然科学基金;

关键词：

Intestine; ischemia-reperfusion injury; noncoding RNA; micro RNA; circular RNA; long noncoding RNA; HYDROGEN-RICH SALINE; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; DOWN-REGULATION; KAPPA-B; DOPAMINERGIC-NEURONS; REGULATED MIR-21; UP-REGULATION; STEM-CELLS; PROTECTS;

D O I：

10.2174/0929867330666221219094145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intestinal ischemia-reperfusion injury is a relatively common clinical condition that seriously threatens the prognosis of patients; however, the exact mechanism of intestinal ischemia-reperfusion injury has not been clarified. Recent studies have found that noncoding RNAs, including but not limited to lncRNA, circRNA, and miRNA, play an important role in the pathogenesis of intestinal ischemia-reperfusion. The findings cited in this paper reveal the expression, function, and mechanism of noncoding RNAs during intestinal ischemia-reperfusion. The mechanistic roles of noncoding RNAs in the occurrence and development of intestinal ischemia-reperfusion are discussed, including cell proliferation, autophagy, oxidative stress, apoptosis, oxidative stress, iron death, and many other aspects. However, many unknown mechanisms of association between noncoding RNAs and intestinal ischemia-reperfusion remain to be investigated.

引用

页码：4130 / 4148

页数：19

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