Photoreceptor changes in Leber hereditary optic neuropathy with m.G11778A mutation

? AIM: To evaluate the functional and structural changes of photoreceptors in patients and asymptomatic carriers with Leber hereditary optic neuropathy (LHON) using full -field electroretinography (FERG) and optical coherence tomography (OCT). ? METHODS: Individuals diagnosed with LHON at the Renmin Hospital of Wuhan University and their family members were included in this cross-sectional observational study. The FERG a-wave amplitude of affected patients and asymptomatic carriers was analyzed. The thickness of the outer nuclear layer (ONL), inner and outer segment (IS/OS) and total photoreceptors in the macular fovea and parafovea were measured. ? RESULTS: This study included 14 LHON patients (mean age: 20.00 & PLUSMN;9.37y), 12 asymptomatic carriers (mean age: 39.83 & PLUSMN;6.48y), and 14 normal subjects (mean age: 24.20 & PLUSMN;1.52y). The FERG results showed that the dark -adapted 3.0 electroretinography and light-adapted 3.0 electroretinography a-wave amplitudes of patients and carriers were significantly decreased (P<0.001). The ONL and photoreceptors layers were slightly thicker in patients than in normal subjects (P<0.05), whereas they were thinner in carriers (P<0.05). There were no differences in IS/OS thickness among the groups (P>0.05). ? CONCLUSION: Photoreceptors function is significantly impaired in LHON-affected patients and asymptomatic carriers. Meanwhile, photoreceptors morphology is slightly altered, mainly manifesting as a change in ONL thickness.