Breast cancer heterogeneity and its implication in personalized precision therapy

被引：153

作者：

Guo, Liantao ^{[1
]}

Kong, Deguang ^{[1
]}

Liu, Jianhua ^{[1
]}

Zhan, Ling ^{[1
]}

Luo, Lan ^{[3
]}

Zheng, Weijie ^{[1
]}

Zheng, Qingyuan ^{[2
]}

Chen, Chuang ^{[1
]}

Sun, Shengrong ^{[1
]}

机构：

[1] Wuhan Univ, Dept Breast & Thyroid Surg, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China

[2] Wuhan Univ, Dept Urol, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China

[3] Guizhou Med Univ, Dept Breast Surg, Affiliated Hosp, 28 Guiyi Rd, Guiyang 550001, Guizhou, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2023年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Breast cancer; Heterogeneity; Cell interaction; Cell competition; Precision therapy; TUMOR-ASSOCIATED MACROPHAGES; ANTIBODY-DRUG CONJUGATE; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CELL INTERACTIONS; SINGLE-CELL; PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTOR; GENE-EXPRESSION; MOLECULAR CHARACTERIZATION; ANTITUMOR-ACTIVITY;

D O I：

10.1186/s40164-022-00363-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize the origins of breast cancer heterogeneity and its influence on disease progression, recurrence, and therapeutic resistance. We review the possible mechanisms of heterogeneity and the research methods used to analyze it. We also highlight the importance of cell interactions for the origins of breast cancer heterogeneity, which can be further categorized into cooperative and competitive interactions. Finally, we provide new insights into precise individual treatments based on heterogeneity.

引用

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